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Effect of Beta Blockers on the Hemodynamics and Thrombotic Risk of Coronary Artery Aneurysms in Kawasaki Disease

Journal of Cardiovascular Translational Research (2023)Cite this article

Abstract

This study aims to simulate beta blockers’ (BB) effects on coronary artery aneurysms’ (CAA) hemodynamics and thrombotic risk in Kawasaki disease (KD). BB are recommended in cases of large aneurysms due to their anti-ischemic effect. Coronary blood flow (CBF) was simulated in KD patient-specific CAA models using computational fluid dynamics. Hemodynamic indices that correlate with thrombotic risk were calculated following two possible responses to BB: (1) preserved coronary flow (third BB generation) and (2) reduction in coronary flow (first and second BB generations) at reduced heart rate. Following CBF reduction scenario, mean TAWSS and HOLMES significantly decreased compared to normal conditions, leading to a potential increase in thrombotic risk. Preserved CBF at lower heart rates, mimicking the response to vasodilating BBs, does not significantly affect local CAA hemodynamics compared with baseline, while achieving the desired anti-ischemic effects. Different BB generations lead to different hemodynamic responses in CAA.

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Funding

This work was partially funded by Michigan Technological University’s Research Excellence Fund. Alireza Asadbeygi was partly funded by the Blue Cross Blue Shield of Michigan Foundation. No other external funding was received.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Michigan Technological University, 1400 Townsend Dr , Houghton, MI, 49931, USA

    Alireza Asadbeygi & Hoda Hatoum

  2. Department of Pediatrics, Nationwide Children’s Hospital, Columbus, OH, USA

    Simon Lee & John Kovalchin

  3. Health Research Institute, Center of Biocomputing and Digital Health and Institute of Computing and Cybernetics, Michigan Technological University, Houghton, MI, USA

    Hoda Hatoum

Authors
  1. Alireza Asadbeygi
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  2. Simon Lee
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  4. Hoda Hatoum
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Corresponding author

Correspondence to Hoda Hatoum.

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Conflict of Interest

Alireza Asadbeygi reports financial support was provided by Blue Cross Blue Shield of Michigan Foundation. Hoda Hatoum reports financial support was provided by Michigan Technological University. Hoda Hatoum reports a relationship with Dasi Simulations LLC that includes board membership. Hoda Hatoum has patent pending to Georgia Institute of Technology. Hoda Hatoum has patent pending to Georgia Institute of Technology and the Ohio State University.

Disclosures

Dr. Hatoum filed a patent application on computational predictive modeling of thrombosis in heart valves and on a novel implantable vascular shunt with real-time precise flow control. She is a member of the scientific advisory board at Dasi Simulations LLC.

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Associate Editor Jozine ter Maaten oversaw the review of this article

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Asadbeygi, A., Lee, S., Kovalchin, J. et al. Effect of Beta Blockers on the Hemodynamics and Thrombotic Risk of Coronary Artery Aneurysms in Kawasaki Disease. J. of Cardiovasc. Trans. Res. (2023). https://doi.org/10.1007/s12265-023-10370-0

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  • DOI: https://doi.org/10.1007/s12265-023-10370-0

Keywords

  • Coronary artery aneurysm (CAA)
  • Thrombosis
  • Beta blockers (BB)
  • Kawasaki disease (KD)
  • Computational fluid dynamics (CFD)
  • Particle residence time

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