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Lipid Droplet—a New Target in Ischemic Heart Disease

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Abstract

Lipid droplet (LD) is a kind of subcellular organelle, which originates from the endoplasmic reticulum (ER). LDs can move flexibly between other organelles and store energy in the cells. In recent years, LDs and lipid droplet–associated proteins have attracted added attention at home and abroad, especially in cardiovascular diseases. Cardiovascular diseases, especially ischemic heart disease (IHD), have always been the focus of attention because of their high morbidity and mortality. Atherosclerosis and myocardial remodeling are two important pathologic processes of IHD, and LDs and other organelles are involved in the development of the disease. The interaction between LDs and ER is involved in the formation of foam cells in atherosclerosis. And LDs, mitochondria, and lysosomes also affect the remodeling of cardiomyocytes by affecting ROS production and regulating PI3K/AKT pathways. In this article, we will review the role of LDs in IHD.

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The datasets used or analyzed during the current study are available from the corresponding author on reasonable request.

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Funding

This work was supported by the National Natural Science Foundation of China (81774232); National Youth Natural Science Foundation of China (82104721); the Second Batch of National “Ten Thousand Talents Program” Project Leading Talents (20160621); and Scientific Research Program of Tianjin Education Commission (2019KJ059).

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  1. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China

    Xiaoying Guo, Qi Shi, Wanqin Zhang, Zhongwen Qi, Hao Lv, Fujing Man, Yaping Zhu & Junping Zhang

  2. National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China

    Xiaoying Guo, Qi Shi, Wanqin Zhang, Zhongwen Qi, Hao Lv, Fujing Man, Yaping Zhu & Junping Zhang

  3. Tianjin University of Traditional Chinese Medicine, Tianjin, China

    Xiaoying Guo, Qi Shi, Wanqin Zhang, Zhongwen Qi, Hao Lv, Fujing Man & Yingyu Xie

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  1. Xiaoying Guo
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Contributions

Xiaoying Guo and Qi Shi contributed to the conception of and writing of the manuscript.

Wanqin Zhang, Zhongwen Qi, Hao Lv, and Fujing Man contributed significantly to analysis and manuscript preparation.

Yingyu Xie, Yaping Zhu, and Junping Zhang helped perform the analysis with constructive discussions.

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Correspondence to Yingyu Xie or Junping Zhang.

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Yingyu Xie and Junping Zhang contributed equally to this work.

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Guo, X., Shi, Q., Zhang, W. et al. Lipid Droplet—a New Target in Ischemic Heart Disease. J. of Cardiovasc. Trans. Res. 15, 730–739 (2022). https://doi.org/10.1007/s12265-021-10204-x

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