Brain injury is a major source of patient morbidity after cardiac surgery in children. New early accurate biomarkers are needed for the diagnosis of patients at risk for cerebral postoperative damage. Specific circulating miRNAs have been found as suitable biomarkers for many diseases. We tested whether miRNA-124a reflects neurological injury in pediatric patients following heart surgery. Serum samples were obtained from 34 patients before and six hours after heart surgery. MiRNAs-124a was quantified by RQ-PCR. MiRNA-124a levels six hours after heart surgery correlated with the neurological outcome of the patients. In children with neurological deficits, miRNA-124a levels increased while in those with no neurological deficits the levels decreased. MiRNA-124a was able, at six hours after the operation, to identify patients who are at risk for the appearance of neurological deficits. Circulating miRNA-124a is a potential biomarker for the appearance of neurological deficits in pediatric patients following heart surgery.
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congenital heart disease
extracorporeal membrane oxygenation
pediatric stroke outcome measure
Glasgow Coma Scale
postoperative cognitive dysfunction
hypoxic ischemic encephalopathy
Risk-Adjusted Classification for Congenital Heart Surgery
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We thank Amisragas for their continuous support of the Department of Intensive Care. This study was performed at the Department of Pediatric Critical Care Medicine, Safra Children’s Hospital, Sheba Medical Center, Tel Hashomer, Israel.
This work was funded with institutional departmental funds.
Ethics Approval and Consent to Participate
All procedures followed were in accordance with the ethical standards of the institutional and national committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from all patients for being included in the study. No animal studies were carried out by the authors for this article.
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Associate Editor Marat Fudim oversaw the review of this article
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Zloto, K., Mor, L., Bar-Yosef, O. et al. MiRNA-124a: a Potential Biomarker for Neurological Deficits Following Cardiac Surgery in Pediatric Patients. J. of Cardiovasc. Trans. Res. (2021). https://doi.org/10.1007/s12265-021-10127-7
- Neurological deficit
- Congenital heart disease
- Pediatric cardiac surgery