Abstract
Acute pulmonary embolism (APE) is a common sudden venous thromboembolism with high rates of morbidity and mortality. Several studies have concluded that microRNA-134 could be a potential biomarker for APE. However, the sensitivity of these studies varies widely. This study aimed to evaluate the diagnostic value of circulating microRNA-134 levels for APE. Four databases were searched to retrieve articles focusing on microRNA-134 detection in APE diagnosis. The Quality Assessment of Diagnostic Accuracy Studies-2 was used to evaluate the quality of the included literature. This meta-analysis included seven studies and 383 subjects. The microRNA-134 levels in APE patients were higher than those in controls (SMD = 2.84, z = 3.69, p < 0.001). The pooled sensitivity, specificity, and diagnostic odds ratio were 0.86 (0.72–0.94), 0.75 (0.66–0.82), and 19 (7–51), respectively. The positive and negative likelihood ratios were 3.4 (2.4–4.8) and 0.18 (0.08–0.40), respectively. The area under the summary receiver operating characteristic curve was 0.81 (0.77–0.84). Circulating microRNA-134 may be a new biomarker for the diagnosis of APE, but more tests and studies are needed to further explore and prove this. Trial registration number: PROSPERO registration #CRD42020184072
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Abbreviations
- APE:
-
Acute pulmonary embolism
- NSTEMI:
-
Non-ST segment elevation myocardial infarction
- SROC:
-
Summary receiver operating characteristic
- AUC:
-
The area under the summary receiver operating characteristic curve
- SEN:
-
Sensitivity
- SPE:
-
Specificity
- PLR:
-
Positive likelihood ratio
- NLR:
-
Negative likelihood ratio
- DOR:
-
Diagnostic odds ratio
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Acknowledgments
Thanks to Associate Professor Yu Xiaojin, Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, for her help and guidance in data processing and analysis.
Funding
This study was funded by Key Research and Development Project of Hebei Province: Study on circulating biomarkers of acute pulmonary thromboembolism and its application value in risk stratification and prognosis evaluation (grant number 182777198).
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Liu, Y., Xie, M., Gao, X. et al. Predictive Value of Circulating microRNA-134 Levels for Early Diagnosis of Acute Pulmonary Embolism: Meta-analysis. J. of Cardiovasc. Trans. Res. 14, 744–753 (2021). https://doi.org/10.1007/s12265-020-10087-4
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DOI: https://doi.org/10.1007/s12265-020-10087-4