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Enhancing Matured Stem-Cardiac Cell Generation and Transplantation: A Novel Strategy for Heart Failure Therapy

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Abstract

Heart failure (HF) remains one of the major causes of morbidity and mortality worldwide. Recent studies have shown that stem cells (SCs) including bone marrow mesenchymal stem (BMSC), embryonic bodies (EB), embryonic stem (ESC), human induced pluripotent stem (hiPSC)-derived cardiac cells generation, and transplantation treated myocardial infarction (MI) in vivo and in human. However, the immature phenotypes compromise their clinical application requiring immediate intervention to improve stem-derived cardiac cell (S-CCs) maturation. Recently, an unbiased multi-omic analysis involving genomics, transcriptomics, epigenomics, proteomics, and metabolomics identified specific strategies for the generation of matured S-CCs that may enhance patients’ recovery processes upon transplantation. However, these strategies still remain undisclosed. Here, we summarize the recently discovered strategies for the matured S-CC generation. In addition, cardiac patch formation and transplantation that accelerated HF recuperation in clinical trials are discussed. A better understanding of this work may lead to efficient generation of matured S-CCs for regenerative medicine.

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Funding

This research was supported by the Natural Science Foundation of Hunan Province, China (2018JJ2346).

Author information

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, University of South China, Hengyang, 421001, Hunan Province, China

    Ampadu O. Jackson & Shiyin Long

  2. International College, University of South China, Hengyang, 421001, Hunan Province, China

    Ampadu O. Jackson

  3. Cape Coast Teaching Hospital, Cape Coast, Department of Surgery, School of Medical Science, University of Cape Coast, Cape Coast, Ghana

    Ampadu O. Jackson & Ganiyu A. Rahman

  4. The Second Affiliated Hospital of Guilin Medical University, Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, China

    Kai Yin

Authors
  1. Ampadu O. Jackson
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  2. Ganiyu A. Rahman
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  3. Kai Yin
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  4. Shiyin Long
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Correspondence to Shiyin Long.

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Jackson, A.O., Rahman, G.A., Yin, K. et al. Enhancing Matured Stem-Cardiac Cell Generation and Transplantation: A Novel Strategy for Heart Failure Therapy. J. of Cardiovasc. Trans. Res. 14, 556–572 (2021). https://doi.org/10.1007/s12265-020-10085-6

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