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High Plasma Myeloperoxidase Is Associated with Plaque Erosion in Patients with ST-Segment Elevation Myocardial Infarction

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Abstract

We aimed to investigate the association between plasma myeloperoxidase (MPO) and plaque erosion in patients presenting with ST-segment elevation myocardial infarction (STEMI). Two hundred and fifty-two patients with STEMI who underwent optical coherence tomography (OCT) evaluation of culprit lesion were prospectively enrolled. Of them, 92 and 80 patients were identified with plaque rupture and plaque erosion, respectively. Plasma MPO levels, measured using enzyme-linked immunoassay, were significantly higher in patients with plaque erosion versus plaque rupture (median (interquartile range), 96.3 ng/mL [44.2–173.3] vs. 41.7 ng/mL (29.2–66.3); p < 0.001). Multivariable logistic regression analysis indicated that plasma MPO was independently associated with plaque erosion (odds ratio, 3.25; 95% confidence interval, 1.37–7.76; p = 0.008). The area under the receiver-operating characteristic curve was 0.75 for MPO to discriminate between plaque erosion and plaque rupture. Plasma MPO level significantly correlated with plaque erosion in patients with STEMI.

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Abbreviations

AMI:

Acute myocardial infarction

AUC:

Area under the receiver-operating characteristic curve

eGFR:

Estimated glomerular filtration rate

MPO:

Myeloperoxidase

OCT:

Optical coherence tomography

PCI:

Percutaneous coronary intervention

STEMI:

ST-segment elevation myocardial infarction

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Funding

This study was supported by the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (2016-I2M-1-009).

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Authors and Affiliations

  1. Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences, 167 Beilishi Road, Xicheng District, Beijing, 100037, China

    Yu Tan, Runzhen Chen, Zhaoxue Sheng, Peng Zhou, Chen Liu, Hanjun Zhao, Li Song, Jiannan Li, Jinying Zhou, Yi Chen & Hongbing Yan

  2. Xiamen Cardiovascular Hospital, Xiamen University, Xiamen, China

    Yu Tan & Shujun Yang

  3. Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen, China

    Hongbing Yan

Authors
  1. Yu Tan
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  2. Shujun Yang
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  11. Yi Chen
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Correspondence to Hongbing Yan.

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The authors declare that they have no conflict of interest.

Ethical Approval

The study was conducted according to the Declaration of Helsinki. The ethical committee of the Fuwai Hospital approved the study. No animal studies were carried out by the authors for this article. Informed consent was obtained from all individual participants included in the study.

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Associate Editor Craig M. Stolen oversaw the review of this article

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Tan, Y., Yang, S., Chen, R. et al. High Plasma Myeloperoxidase Is Associated with Plaque Erosion in Patients with ST-Segment Elevation Myocardial Infarction. J. of Cardiovasc. Trans. Res. 13, 908–915 (2020). https://doi.org/10.1007/s12265-020-10002-x

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