Abstract
Deoxyribonucleic acid (DNA) damage and repair signaling cascades are related to the development of atherosclerosis. Pathological studies have demonstrated that healed coronary plaque rupture (HCPR) contributes to plaque progression and predisposes to sudden ischemic cardiac death. The objective of this study is to investigate the relationship between HCPR detected by optical coherence tomography (OCT) and DNA ligase. Forty-two patients with both OCT and DNA ligase were prospectively enrolled. The population included patients with stable angina pectoris (SA) and non-ST-elevation myocardial infarction (NSTEMI). It was found that the prevalence of HCPR was greater in subjects with higher DNA ligase activity (correlation coefficient 0.36, p = 0.019). The presence of HCPR in patients with NSTEMI was greater than in patients with SA per OCT analysis; however, there was no statistical difference in this limited population (22.53% versus 12.83%, respectively, p = 0.116). DNA repair activity by DNA ligase was associated with HCPR in advanced coronary artery plaque by OCT.
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Ron Waksman has served on the advisory boards of Abbott Vascular, Amgen, Boston Scientific, Medtronic, Philips Volcano, Pi-Cardia Ltd., and Cardioset; has served as a consultant for Abbott Vascular, Amgen, Biosensors, Biotronik, Boston Scientific, Medtronic, Philips Volcano, Pi-Cardia Ltd., and Cardioset; has received grant support from Abbott Vascular, AstraZeneca, Biosensors, Biotronik, Boston Scientific, and Chiesi; has served on the speakers bureaus of AstraZeneca and Chiesi; and is an investor in MedAlliance. All other authors declare that they have no conflicts of interest.
Ethical Approval
All procedures performed in the present study involving human participants were in accordance with the ethical standards of the Research Ethics Service Committee South East Coast-Surrey, United Kingdom (REC Reference: 13/LO/0238, IRAS Project ID: 120221) and with the 1964 Helsinki declaration and its later amendments.
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Informed consent was obtained from all individual participants included in the study.
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Associate Editor Adrian Chester oversaw the review of this article
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Dan, K., Garcia-Garcia, H.M., Yacob, O. et al. Deoxyribonucleic Acid Repair Activity Is Associated with Healed Coronary Plaque Rupture by Optical Coherence Tomography. J. of Cardiovasc. Trans. Res. 12, 608–610 (2019). https://doi.org/10.1007/s12265-019-09904-2
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DOI: https://doi.org/10.1007/s12265-019-09904-2