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Right Ventricular Function After Pulmonary Artery Banding: Adaptive Processes Assessed by CMR and Conductance Catheter Measurements in Sheep

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Abstract

This experimental study describes the adaptive processes of the right ventricular (RV) myocardium after pulmonary artery banding (PAB) evaluated by cine cardiac magnetic resonance (CMR), phase-contrast CMR (PC-CMR), and conductance catheter. Seven sheep were subjected to CMR 3 months after PAB. Conductance catheter measurements were performed before and 3 months after PAB. Four nonoperated, healthy, age-matched animals served as controls. Higher RV masses (p < 0.01), elevated RV end-systolic volumes (p < 0.05), and lower RV ejection fraction (p < 0.01) were observed in the operated group. The time-to-peak pulmonary artery flow was longer in the banding group (p < 0.01). RV maximal pressure and RV end-diastolic pressure correlated with the time-to-peak flow in the pulmonary artery (r = − 0.70 and − 0.69, respectively). In summary, PAB caused RV hypertrophy, increased myocardial contractility, and decreased RV-EF and cardiac output. The time-to-peak pulmonary artery flow correlated with RV pressures.

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Abbreviations

RV:

Right ventricle

PA:

Pulmonary artery

PAB:

Pulmonary artery banding

CMR:

Cardiac magnetic resonance

PC-CMR:

Phase-contrast cardiac magnetic resonance

EF:

Ejection fraction

ESV:

End-systolic volume

EDV:

End-diastolic volume

SV:

Stroke volume

RV-Pmax :

RV maximal systolic pressure

RV-EDP:

Right ventricular end-diastolic pressure

RV-ESP:

Right ventricular end-systolic pressure

RV-dP/dtmax :

Right ventricular maximum rate of pressure rise

RV-dP/dtmin :

Right ventricular minimum rate of pressure rise

RV-CO:

Right ventricular cardiac output

RV-EDPVR:

RV end-diastolic pressure-volume relationship

RV-ESPVR:

RV end-systolic pressure-volume relationship

RV-PRSW:

RV preload-recruitable stroke work

SSFP:

Steady-state free precession

ECG:

Electrocardiogram

TVA:

Tricuspid valve annulus

TVA-MD:

Tricuspid valve annulus maximal longitudinal displacement

TVA-Vmax :

Tricuspid valve annulus maximal velocity

TVA-VED :

Tricuspid valve annulus maximal velocity at end diastole

TTP:

Time-to-peak

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Funding

This research received no grant from any funding agency in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Diagnostic and Interventional Radiology, University Clinic, Schillingallee 35, 10857, Rostock, Germany

    Hubert Gufler & Sabine Wagner

  2. Clinic and Policlinic of Radiology, Martin-Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06120, Halle, Germany

    Hubert Gufler

  3. Department of Cardiac Surgery, University Clinic, Schillingallee 35, 10857, Rostock, Germany

    Sabine Niefeldt, Stephanie Prietz, Christian Klopsch & Can Yerebakan

  4. Fraunhofer Research Institution for Marine Biotechnology, Department of Medical Cell Technology and Institute for Medical and Marine Biotechnology, University of Lübeck, Lübeck, Germany

    Johannes Boltze

  5. Institute for Experimental Surgery, Rostock University Medical Center, Schillingallee 69a, 18057, Rostock, Germany

    Brigitte Vollmar

  6. University of Warwick, School of Life Science, Gibbet Hill Road, CV4 7AL, Coventry, United Kingdom

    Johannes Boltze

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  1. Hubert Gufler
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  2. Sabine Niefeldt
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Correspondence to Hubert Gufler.

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This study was approved by the local Animal Care Committee. Animals received humane care in compliance with the Principles of Laboratory Animal Care formulated by the National Society for Medical Research and the Guide for the Care and Use of Laboratory Animals.

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Associate Editor Ana Barac oversaw the review of this article

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Gufler, H., Niefeldt, S., Boltze, J. et al. Right Ventricular Function After Pulmonary Artery Banding: Adaptive Processes Assessed by CMR and Conductance Catheter Measurements in Sheep. J. of Cardiovasc. Trans. Res. 12, 459–466 (2019). https://doi.org/10.1007/s12265-019-09881-6

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  • DOI: https://doi.org/10.1007/s12265-019-09881-6

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