Skip to main content
Log in

The Dynamics of Cardiovascular Biomarkers in non-Elite Marathon Runners

  • Correspondence
  • Published:
Journal of Cardiovascular Translational Research Aims and scope Submit manuscript

Abstract

The number of recreational/non-elite athletes participating in marathons is increasing, but data regarding impact of endurance exercise on cardiovascular health are conflicting. This study evaluated 79 recreational athletes of the 2016 Barcelona Marathon (72% men; mean age 39 ± 6 years; 71% ≥35 years). Blood samples were collected at baseline (24–48 h before the race), immediately after the race (1–2 h after the race), and 48-h post-race. Amino-terminal pro-B type natriuretic peptide (NT-proBNP, a marker of myocardial strain), ST2 (a marker of extracellular matrix remodeling and fibrosis, inflammation, and myocardial strain), and high-sensitivity troponin T (hs-TnT, a marker of myocyte stress/injury) were assayed. The median (interquartile range, IQR) years of training was 7 (5–11) years and median (IQR) weekly training hours was 6 (5–8) h/week, respectively. The median (IQR) race time (h:min:s) was 3:32:44 (3:18:50–3:51:46). Echocardiographic indices were within normal ranges. Immediately after the race, blood concentration of the three cardiac biomarkers increased significantly, with 1.3-, 1.6-, and 16-fold increases in NT-proBNP, ST2, and hs-TnT, respectively. We found an inverse relationship between weekly training hours and increased ST2 (p = 0.007), and a direct relationship between race time and increased hs-TnT (p < 0.001) and ST2 (p = 0.05). Our findings indicate that preparation for and participation in marathon running may affect multiple pathways affecting the cardiovascular system. More data and long-term follow-up studies in non-elite and elite athletes are needed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Lee, D. C., Pate, R. R., Lavie, C. J., Sui, X., Church, T. S., & Blair, S. N. (2014). Leisure-time running reduces all-cause and cardiovascular mortality risk. Journal of the American College of Cardiology, 64, 472–481.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Bayes-Genis, A., Januzzi, J. L., Gaggin, H. K., de Antonio, M., Motiwala, S. R., Zamora, E., Galán, A., Domingo, M., Urrutia, A., & Lupón, J. (2015). ST2 pathogenetic profile in ambulatory heart failure patients. Journal of Cardiac Failure, 21, 355–361.

    Article  CAS  PubMed  Google Scholar 

  3. Neilan, T. G., Januzzi, J. L., Lee-Lewandrowski, E., et al. (2006). Myocardial injury and ventricular dysfunction related to training levels among nonelite participants in the Boston marathon. Circulation, 114, 2325–2333.

    Article  PubMed  Google Scholar 

  4. Ford, I., Shah, A. S., Zhang, R., et al. (2016). High-sensitivity cardiac troponin, statin therapy, and risk of coronary heart disease. Journal of the American College of Cardiology, 68, 2719–2728.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Antoni Bayes-Genis.

Ethics declarations

Funding

No funding.

Conflict of Interest

AB-G, JLJ, and JL have participated in lectures from Roche and Critical Diagnostics. PL has no disclosures. AB-G has received honoraria for lectures from Roche Diagnostics and Critical Diagnostics. AB-G has received grants from Roche Diagnostics.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Additional information

Associate Editor Craig Stolen oversaw the review of this article

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Roca, E., Nescolarde, L., Lupón, J. et al. The Dynamics of Cardiovascular Biomarkers in non-Elite Marathon Runners. J. of Cardiovasc. Trans. Res. 10, 206–208 (2017). https://doi.org/10.1007/s12265-017-9744-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12265-017-9744-2

Keywords

Navigation