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Metabolomics in the Diagnosis of Acute Myocardial Ischemia

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Abstract

Despite recent advances in the diagnosis of myocardial ischemia, its biochemical identification in patients with acute chest pain is still a challenge, and alternative approaches for further improvement are needed. Metabolic alterations are the first consequences of acute myocardial ischemia. Metabolomics coupled with potent multivariate analyses allows for a simultaneous and relative quantification of thousands of different metabolites within a given sample. Thus, this discipline might exert a great impact on medical practice in cardiovascular medicine by providing a wealth of relevant biochemical data. Metabolomics is a promising tool to improve current, single biomarker-based approaches by identifying metabolic biosignatures that embody global biochemical changes in disease. This is especially relevant for conditions requiring early treatment like myocardial ischemia. This review discusses the potential application of metabolomics in the diagnosis of myocardial ischemia.

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Acknowledgments

This review was supported by the Instituto de Salud Carlos III: PI011/02323 (VB) and RIC (FJC); by the Generalitat Valenciana: PROMETEO2013/007 (VB), GVASAN AP014/2009 (DM) and PROMETEO2010-075 (JRV); and by the Regensburger Forschungsförderung in der Medizin (ReForM) (OH).

Conflicts of interest

No conflict of interest exists in the present study. All authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

Author information

Authors and Affiliations

  1. Cardiology Department, Hospital Clinico Universitario, INCLIVA, University of Valencia, Blasco Ibanez 17, 46010, Valencia, Spain

    Vicente Bodi & Francisco J. Chorro

  2. Laboratory of Metabolomics, INCLIVA, University of Valencia, Valencia, Spain

    Vannina G. Marrachelli & Daniel Monleon

  3. Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Munich, Germany

    Oliver Husser

  4. Klinik und Poliklinik für Innere Medizin II, University of Regensburg Medical Center, Regensburg, Germany

    Oliver Husser

  5. Department of Biochemistry and Molecular Biology, INCLIVA, University of Valencia, Valencia, Spain

    Juan R. Viña

Authors
  1. Vicente Bodi
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  2. Vannina G. Marrachelli
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  3. Oliver Husser
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  4. Francisco J. Chorro
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  5. Juan R. Viña
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  6. Daniel Monleon
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Corresponding authors

Correspondence to Vicente Bodi or Daniel Monleon.

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Associate Editor Enrique Lara-Pezzi oversaw the review of this article

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Bodi, V., Marrachelli, V.G., Husser, O. et al. Metabolomics in the Diagnosis of Acute Myocardial Ischemia. J. of Cardiovasc. Trans. Res. 6, 808–815 (2013). https://doi.org/10.1007/s12265-013-9505-9

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  • DOI: https://doi.org/10.1007/s12265-013-9505-9

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