Abstract
We examined whether there is a relationship between repolarization abnormalities on electrocardiography (EKG) and deformation abnormalities by echocardiography. Analysis of baseline EKGs and mechanical (echo-based deformation) changes was performed in 128 patients with a clinical diagnosis of hypertrophic cardiomyopathy (HCM). Patients with left ventricular hypertrophy (LVH) or repolarization abnormalities had higher septal thickness when compared to patients with normal EKG. Patients with EKG evidence of LVH or QTc prolongation had lower systolic velocity, systolic strain, systolic strain rate, late diastolic velocity, and late diastolic strain rate than patients with a normal EKG. Patients with strain pattern or ST depression/T-wave inversion had lower systolic velocity, systolic strain, systolic strain rate, early diastolic velocity, and late diastolic velocity when compared to patients with normal EKGs. LVH and repolarization abnormalities on surface EKG are markers of impaired systolic and diastolic mechanics in HCM.
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Funding for this study was provided by National Institutes of Health grant # HL 098046. Dr. Lin was partially supported by the China Scholarship Council. The experiments comply with the current laws of the USA.
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Associate Editor: Jozef Bartunek oversaw the review of this article
Xiaoping Lin and Hsin-Yueh Liang contributed equally to this work.
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Lin, X., Liang, HY., Pinheiro, A. et al. Electromechanical Relationship in Hypertrophic Cardiomyopathy. J. of Cardiovasc. Trans. Res. 6, 604–615 (2013). https://doi.org/10.1007/s12265-013-9481-0
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DOI: https://doi.org/10.1007/s12265-013-9481-0