Skip to main content
SpringerLink
Log in

Association Between Endothelial Nitric Oxide Synthase Polymorphisms and Atrial Fibrillation: A Meta-analysis

  • Published:
Journal of Cardiovascular Translational Research Aims and scope Submit manuscript

Abstract

Several recent studies have focused on the association between the promoter polymorphisms 786T/C of the endothelial nitric oxide synthase (eNOS) gene and susceptibility to atrial fibrillation (AF); however, results have been conflicting. We searched Medline, Embase, and the ISI Web of Science through July 1, 2011. Five studies with 1,130 AF cases and 2,340 controls were selected. Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated based on fixed- and random-effects models. There was no overall association between eNOS 786T/C and AF risk. In subgroup analysis, stratified by ethnicity, we observed a positive association between the eNOS 786T/C polymorphism and AF risk among Caucasians but not among mixed populations. When stratifying by control source, the overall ORs for population- and hospital-based studies were 1.07 (95 % CI, 0.50–2.30) and 0.79 (95 % CI, 0.65–0.97) for CC vs. 22T carriers, respectively. In the studies with a sample size greater than 200, the eNOS 786T/C polymorphism decreased AF risk (OR [95 % CI]: 0.79 [0.64–0.97] for CC vs. T carriers). This meta-analysis suggests that the 786T/C polymorphism of the eNOS gene is protective against AF risk among Caucasians. Additional large studies based on diverse populations are required to validate this conclusion.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Holmqvist, F., Olesen, M. S., Tveit, A., Enger, S., Tapanainen, J., Jurkko, R., et al. (2011). Abnormal atrial activation in young patients with lone atrial fibrillation. Europace, 13, 188–192.

    Article  PubMed  Google Scholar 

  2. Klemenz, B. (2011). Screening for atrial fibrillation. British Journal of General Practice, 61, 295.

    Article  PubMed  Google Scholar 

  3. Lupo, P., & Cappato, R. (2010). Atrial fibrillation ablation in the real world. G Ital Cardiol (Rome), 11, 17S–20S.

    Google Scholar 

  4. Murray, S., Lazure, P., Pullen, C., Maltais, P., & Dorian, P. (2011). Atrial fibrillation care: challenges in clinical practice and educational needs assessment. Canadian Journal of Cardiology, 27, 98–104.

    Article  PubMed  Google Scholar 

  5. Patterson, S., Wolfe, D. A., & Bower, B. (2010). Atrial fibrillation. A concise update on treatment. Advance for NPs and PAs, 1(20–2), 4.

    Google Scholar 

  6. Kopec, J. A., & Esdaile, J. M. (1990). Bias in case–control studies. A review. Journal of Epidemiology Community Health, 44, 179–186.

    Article  PubMed  CAS  Google Scholar 

  7. Marangoni, K., Araujo, T. G., Neves, A. F., & Goulart, L. R. (2008). The -786T>C promoter polymorphism of the NOS3 gene is associated with prostate cancer progression. BMC Cancer, 8, 273.

    Article  PubMed  Google Scholar 

  8. Brenol, C. V., Chies, J. A., Brenol, J. C., Monticielo, O. A., Franciscatto, P., Birriel, F., et al. (2009). Endothelial nitric oxide synthase T-786 C polymorphism in rheumatoid arthritis: association with extraarticular manifestations. Clinical Rheumatology, 28, 201–205.

    Article  PubMed  Google Scholar 

  9. Nagassaki, S., Herculano, R. D., Graeff, C. F., & Tanus-Santos, J. E. (2009). eNOS T-786 C polymorphism affects atorvastatin-induced changes in erythrocyte membrane fluidity. European Journal of Clinical Pharmacology, 65, 385–392.

    Article  PubMed  CAS  Google Scholar 

  10. Jabrocka-Hybel, A., Kolasinska-Kloch, W., Malczewska-Malec, M., Kiec-Wilk, B., Kwasniak, M., Kloch, M., et al. (2007). Gene polymorphisms predisposing to cardiac hypertrophy in patients with cardiac syndrome X. Folia Medica Cracoviensia, 48, 57–69.

    PubMed  CAS  Google Scholar 

  11. Xu, L. X., Yang, W. Y., Zhang, H. Q., Tao, Z. H., & Duan, C. C. (2008). Study on the correlation between CETP TaqIB, KCNE1 S38G and eNOS T-786 C gene polymorphisms for predisposition and non-valvular atrial fibrillation. Zhonghua Liu Xing Bing Xue Za Zhi, 29, 486–492.

    PubMed  CAS  Google Scholar 

  12. van Beynum, I. M., Mooij, C., Kapusta, L., Heil, S., den Heijer, M., & Blom, H. J. (2008). Common 894G>T single nucleotide polymorphism in the gene coding for endothelial nitric oxide synthase (eNOS) and risk of congenital heart defects. Clinical Chemistry and Laboratory Medicine, 46, 1369–1375.

    Article  PubMed  Google Scholar 

  13. Huttunen, R., Hurme, M., Laine, J., Eklund, C., Vuento, R., Aittoniemi, J., et al. (2009). Endothelial nitric oxide synthase G894T (GLU298ASP) polymorphism is associated with hypotension in patients with E. coli bacteremia but not in bacteremia caused by a gram-positive organism. Shock, 31, 448–453.

    Article  PubMed  CAS  Google Scholar 

  14. Fatini, C., Sticchi, E., Genuardi, M., Sofi, F., Gensini, F., Gori, A. M., et al. (2006). Analysis of minK and eNOS genes as candidate loci for predisposition to non-valvular atrial fibrillation. European Heart Journal, 27, 1712–1718.

    Article  PubMed  CAS  Google Scholar 

  15. Gensini, F., Padeletti, L., Fatini, C., Sticchi, E., Gensini, G. F., & Michelucci, A. (2003). Angiotensin-converting enzyme and endothelial nitric oxide synthase polymorphisms in patients with atrial fibrillation. Pacing and Clinical Electrophysiology, 26, 295–298.

    Article  PubMed  Google Scholar 

  16. Giusti, B., Gori, A. M., Marcucci, R., Sestini, I., Saracini, C., Sticchi, E., et al. (2007). Role of C677T and A1298C MTHFR, A2756G MTR and −786 C/T eNOS gene polymorphisms in atrial fibrillation susceptibility. PLoS One, 2, e495.

    Article  PubMed  Google Scholar 

  17. Bedi, M., McNamara, D., London, B., & Schwartzman, D. (2006). Genetic susceptibility to atrial fibrillation in patients with congestive heart failure. Heart Rhythm, 3, 808–812.

    Article  PubMed  Google Scholar 

  18. Kavvoura F. K., & Ioannidis J. P. (2005). CTLA-4 gene polymorphisms and susceptibility to type 1 diabetes mellitus: a HuGE review and meta-analysis. American Journal of Epidemiol, 162(1), 3–16.

    Google Scholar 

  19. Xi, B., Zeng, T., Liu, L., Liang, Y., Liu, W., Hu, Y., et al. (2011). Association between polymorphisms of the renin-angiotensin system genes and breast cancer risk: a meta-analysis. Breast Cancer Research and Treatment, 130(2), 561–568.

    Article  PubMed  CAS  Google Scholar 

  20. Liu, T., Korantzopoulos, P., Xu, G., Shehata, M., Li, D., Wang, X., et al. (2011). Association between angiotensin-converting enzyme insertion/deletion gene polymorphism and atrial fibrillation: a meta-analysis. Europace, 13, 346–354.

    Article  PubMed  Google Scholar 

  21. Liu, L., Wang, K., Zhu, Z. M., & Shao, J. H. (2011). Associations between P53 Arg72Pro and development of digestive tract cancers: a meta-analysis. Archives of Medical Research, 42, 60–69.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cardiology, Yantai Yu Huang Ding Hospital, Yantai, 264000, Shandong Province, China

    Hongying Chen, Hongxia Chu, Yu Shi, Jian ping Li, Shao Rong Liu & Jun Yang

  2. College of Public Health, University of Nebraska Medical Center, Omaha, NE, 68198-4350, USA

    Soumitra Sudip Bhuyan

Authors
  1. Hongying Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hongxia Chu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yu Shi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Soumitra Sudip Bhuyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jian ping Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Shao Rong Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jun Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jun Yang.

Additional information

Hongying Chen and Hongxia Chu are equally contributing authors.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chen, H., Chu, H., Shi, Y. et al. Association Between Endothelial Nitric Oxide Synthase Polymorphisms and Atrial Fibrillation: A Meta-analysis. J. of Cardiovasc. Trans. Res. 5, 528–534 (2012). https://doi.org/10.1007/s12265-012-9375-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12265-012-9375-6

Keywords

Search

Navigation