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Adipose-derived Stem Cells for Myocardial Infarction

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Abstract

In recent years, stem cell treatment of myocardial infarction has elicited great enthusiasm upon scientists and physicians alike, thus making the finding of a suitable cell a compulsory subject for modern medicine. Due to its potential, accessibility and efficiency of harvesting, adipose tissue has become one of the most attractive sources of stem cells for regenerative therapies. The differentiation capacity and the paracrine activity of these cells has made them an optimal candidate for the treatment of a diverse range of diseases from immunological disorders as graft versus host disease to cardiovascular pathologies like peripheral ischemia. In this review, we will focus on the use of stem cells derived from adipose tissue for treatment of myocardial infarction, with special attention to their putative in vivo mechanisms of action.

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Acknowledgements

This work was supported in part by ISCIII PI050168, PI070474, CP09/00333, and ISCIII-RETIC RD06/0014, MICCIN PLE2009-0116, and PSE SINBAD, Gobierno de Navarra (Departamento de Educación), Comunidad de Trabajo de los Pirineos (CTP), European Union Framework Project VII (INELPY), Caja de Ahorros de Navarra (Programa Tu Eliges: Tu Decides), and the “UTE project CIMA”.

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  1. Hematology and Cell Therapy and Foundation for Applied Medical Research, Division of Cancer, University of Navarra, Pamplona, Spain

    Manuel Mazo, Beatriz Pelacho & Felipe Prosper

  2. Department of Cardiology and Cardiovascular Surgery, Clínica Universitaria, University of Navarra, Pamplona, Spain

    Juan José Gavira

  3. Hematology and Cell Therapy, Clínica Universidad de Navarra, Av. Pío XII 36, Pamplona, 31008, Spain

    Felipe Prosper

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  1. Manuel Mazo
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Correspondence to Felipe Prosper.

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Mazo, M., Gavira, J.J., Pelacho, B. et al. Adipose-derived Stem Cells for Myocardial Infarction. J. of Cardiovasc. Trans. Res. 4, 145–153 (2011). https://doi.org/10.1007/s12265-010-9246-y

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