Skip to main content
Log in

GABAergic Interneuron Cell Therapy for Drug-Resistant Epilepsy

  • Research Highlight
  • Published:
Neuroscience Bulletin Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Thijs RD, Surges R, O’Brien TJ, Sander JW. Epilepsy in adults. Lancet 2019, 393: 689–701.

    Article  PubMed  Google Scholar 

  2. Collaborators G2E. Global, regional, and national burden of epilepsy, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 2019, 18: 357–375.

  3. de Lanerolle NC, Kim JH, Williamson A, Spencer SS, Zaveri HP, Eid T. A retrospective analysis of hippocampal pathology in human temporal lobe epilepsy: Evidence for distinctive patient subcategories. Epilepsia 2003, 44: 677–687.

    Article  PubMed  Google Scholar 

  4. Kobayashi M, Buckmaster PS. Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy. J Neurosci 2003, 23: 2440–2452.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Hu JS, Vogt D, Sandberg M, Rubenstein JL. Cortical interneuron development: A tale of time and space. Development 2017, 144: 3867–3878.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Casalia ML, Howard MA, Baraban SC. Persistent seizure control in epileptic mice transplanted with gamma-aminobutyric acid progenitors. Ann Neurol 2017, 82: 530–542.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Bershteyn M, Bröer S, Parekh M, Maury Y, Havlicek S, Kriks S, et al. Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy. Cell Stem Cell 2023, 30: 1331-1350.e11.

    Article  CAS  PubMed  Google Scholar 

  8. Upadhya D, Hattiangady B, Castro OW, Shuai B, Kodali M, Attaluri S, et al. Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration. Proc Natl Acad Sci U S A 2019, 116: 287–296.

    Article  ADS  CAS  PubMed  Google Scholar 

  9. Cunningham M, Cho JH, Leung A, Savvidis G, Ahn S, Moon M, et al. hPSC-derived maturing GABAergic interneurons ameliorate seizures and abnormal behavior in epileptic mice. Cell Stem Cell 2014, 15: 559–573.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Zhu Q, Mishra A, Park JS, Liu D, Le DT, Gonzalez SZ, et al. Human cortical interneurons optimized for grafting specifically integrate, abort seizures, and display prolonged efficacy without over-inhibition. Neuron 2023, 111: 807-823.e7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Baraban SC, Southwell DG, Estrada RC, Jones DL, Sebe JY, Alfaro-Cervello C, et al. Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice. Proc Natl Acad Sci U S A 2009, 106: 5472–15477.

    Article  Google Scholar 

Download references

Acknowledgements

This research highlight was supported by grants from the National Natural Science Foundation (82204350) and the Natural Science Foundation of Zhejiang Province (Q22H309365 and LQ22H310007).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Liying Chen.

Ethics declarations

Conflict of interest

The authors declare that there are no conflict of interest.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chen, J., Li, Z., Wang, Y. et al. GABAergic Interneuron Cell Therapy for Drug-Resistant Epilepsy. Neurosci. Bull. (2024). https://doi.org/10.1007/s12264-024-01195-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s12264-024-01195-1

Navigation