Skip to main content
Log in

Propofol Brings on the Light for Depression Therapy

  • Research Highlight
  • Published:
Neuroscience Bulletin Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Marwaha S, Palmer E, Suppes T, Cons E, Young AH, Upthegrove R. Novel and emerging treatments for major depression. Lancet 2023, 401: 141–153.

    Article  CAS  PubMed  Google Scholar 

  2. Li Z, Ruan M, Chen J, Fang Y. Major depressive disorder: Advances in neuroscience research and translational applications. Neurosci Bull 2021, 37: 863–880.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Brechmann T, Maier C, Kaisler M, Vollert J, Schmiegel W, Pak S. Propofol sedation during gastrointestinal endoscopy arouses euphoria in a large subset of patients. United European Gastroenterol J 2018, 6: 536–546.

    Article  CAS  PubMed  Google Scholar 

  4. Jiang Y, Zou M, Wang Y, Wang Y. Nucleus accumbens in the pathogenesis of major depressive disorder: A brief review. Brain Res Bull 2023, 196: 68–75.

    Article  PubMed  Google Scholar 

  5. Zhu XN, Li J, Qiu GL, Wang L, Lu C, Guo YG, et al. Propofol exerts anti-anhedonia effects via inhibiting the dopamine transporter. Neuron 2023, 111: 1626-1636.e6.

    Article  CAS  PubMed  Google Scholar 

  6. Nagata I, Sasaki M, Miyazaki T, Saeki K, Ogawa KI, Kamiya Y. Subanesthetic dose of propofol activates the reward system in rats. Anesth Analg 2022, 135: 414–426.

    Article  CAS  PubMed  Google Scholar 

  7. Luo J, Min S, Wei K, Cao J, Wang B, Li P, et al. Propofol prevents electroconvulsive-shock-induced memory impairment through regulation of hippocampal synaptic plasticity in a rat model of depression. Neuropsychiatr Dis Treat 2014, 10: 1847–1859.

    PubMed  PubMed Central  Google Scholar 

  8. Castro DC, Bruchas MR. A motivational and neuropeptidergic hub: Anatomical and functional diversity within the nucleus accumbens shell. Neuron 2019, 102: 529–552.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Walsh JJ, Han MH. The heterogeneity of ventral tegmental area neurons: Projection functions in a mood-related context. Neuroscience 2014, 282: 101–108.

    Article  CAS  PubMed  Google Scholar 

  10. Park YS, Sammartino F, Young NA, Corrigan J, Krishna V, Rezai AR. Anatomic review of the ventral capsule/ventral Striatum and the nucleus accumbens to guide target selection for deep brain stimulation for obsessive-compulsive disorder. World Neurosurg 2019, 126: 1–10.

    Article  PubMed  Google Scholar 

  11. Lee Y, Subramaniapillai M, Brietzke E, Mansur RB, Ho RC, Yim SJ, et al. Anti-cytokine agents for anhedonia: Targeting inflammation and the immune system to treat dimensional disturbances in depression. Ther Adv Psychopharmacol 2018, 8: 337–348.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Pan Z, Park C, Brietzke E, Zuckerman H, Rong C, Mansur RB, et al. Cognitive impairment in major depressive disorder. CNS Spectr 2019, 24: 22–29.

    Article  PubMed  Google Scholar 

  13. Liu P, Zhao S, Qiao H, Li T, Mi W, Xu Z, et al. Does propofol definitely improve postoperative cognitive dysfunction? A review of propofol-related cognitive impairment. Acta Biochim Biophys Sin 2022, 54: 875–881.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jing Zhao.

Ethics declarations

Conflict of interest

The authors declare that there are no conflicts of interest.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yan, Y., Ma, H. & Zhao, J. Propofol Brings on the Light for Depression Therapy. Neurosci. Bull. 39, 1891–1894 (2023). https://doi.org/10.1007/s12264-023-01133-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12264-023-01133-7

Navigation