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PIKFYVE Inhibition, A Neuronal “Emetic” for Treating ALS?

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References

  1. Dikic I. Proteasomal and autophagic degradation systems. Annu Rev Biochem 2017, 86: 193–224.

    Article  CAS  PubMed  Google Scholar 

  2. Pohl C, Dikic I. Cellular quality control by the ubiquitin-proteasome system and autophagy. Science 2019, 366: 818–822.

    Article  CAS  PubMed  Google Scholar 

  3. Boland B, Yu WH, Corti O, Mollereau B, Henriques A, Bezard E. Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing. Nat Rev Drug Discov 2018, 17: 660–688.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Wilson DM 3rd, Cookson MR, Van Den Bosch L, Zetterberg H, Holtzman DM, Dewachter I. Hallmarks of neurodegenerative diseases. Cell 2023, 186: 693–714.

    Article  CAS  PubMed  Google Scholar 

  5. Hung ST, Linares GR, Chang WH, Eoh Y, Krishnan G, Mendonca S, et al. PIKFYVE inhibition mitigates disease in models of diverse forms of ALS. Cell 2023, 186: 786-802.e28.

    Article  CAS  PubMed  Google Scholar 

  6. van Es MA, Hardiman O, Chio A, Al-Chalabi A, Pasterkamp RJ, Veldink JH, et al. Amyotrophic lateral sclerosis. Lancet 2017, 390: 2084–2098.

    Article  PubMed  Google Scholar 

  7. Taylor JP, Brown RH Jr, Cleveland DW. Decoding ALS: from genes to mechanism. Nature 2016, 539: 197–206.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Shi Y, Lin S, Staats KA, Li Y, Chang WH, Hung ST, et al. Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons. Nat Med 2018, 24: 313–325.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Shisheva A. PIKfyve: partners, significance, debates and paradoxes. Cell Biol Int 2008, 32: 591–604.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Posor Y, Jang W, Haucke V. Phosphoinositides as membrane organizers. Nat Rev Mol Cell Biol 2022, 23: 797–816.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgments

We thank the members of the Fang lab for their comments and critical reading of the manuscript. We apologize for any omission in citing relevant publications due to the reference limit. The research in the Fang lab is supported by grants from the National Natural Science Foundation of China (32270812 and 31970697) and the Science and Technology Commission of Shanghai Municipality (201409003300, 2019SHZDZX02, and 20490712600).

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Correspondence to Yanshan Fang.

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Yue, W., Tang, C.W. & Fang, Y. PIKFYVE Inhibition, A Neuronal “Emetic” for Treating ALS?. Neurosci. Bull. 39, 1738–1740 (2023). https://doi.org/10.1007/s12264-023-01113-x

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  • DOI: https://doi.org/10.1007/s12264-023-01113-x

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