Skip to main content

Advertisement

Log in

Enterochromaffin Cell: Friend or Foe for Human Health?

  • Research Highlight
  • Published:
Neuroscience Bulletin Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Kaelberer MM, Rupprecht LE, Liu WW, Weng P, Bohórquez DV. Neuropod cells: The emerging biology of gut-brain sensory transduction. Annu Rev Neurosci 2020, 43: 337–353.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Dodds KN, Travis L, Kyloh MA, Jones LA, Keating DJ, Spencer NJ. The gut-brain axis: Spatial relationship between spinal afferent nerves and 5-HT-containing enterochromaffin cells in mucosa of mouse colon. Am J Physiol Gastrointest Liver Physiol 2022, 322: G523–G533.

    Article  CAS  PubMed  Google Scholar 

  3. Cremon C, Carini G, Wang B, Vasina V, Cogliandro RF, De Giorgio R. Intestinal serotonin release, sensory neuron activation, and abdominal pain in irritable bowel syndrome. Am J Gastroenterol 2011, 106: 1290–1298.

    Article  CAS  PubMed  Google Scholar 

  4. Gershon MD, Tack J. The serotonin signaling system: From basic understanding to drug development for functional GI disorders. Gastroenterology 2007, 132: 397–414.

    Article  CAS  PubMed  Google Scholar 

  5. Bayrer JR, Castro J, Venkataraman A, Touhara KK, Rossen ND, Morrie RD, et al. Gut enterochromaffin cells drive visceral pain and anxiety. Nature 2023, 616: 137–142.

    Article  CAS  PubMed  Google Scholar 

  6. Bellono NW, Bayrer JR, Leitch DB, Castro J, Zhang C, O’Donnell TA, et al. Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways. Cell 2017, 170: 185-198.e16.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Xu X, Chen R, Zhan G, Wang D, Tan X, Xu H. Enterochromaffin cells: Sentinels to gut microbiota in hyperalgesia? Front Cell Infect Microbiol 2021, 11: 760076.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Yang J, Wang P, Liu T, Lin L, Li L, Kou G, et al. Involvement of mucosal flora and enterochromaffin cells of the caecum and descending colon in diarrhoea-predominant irritable bowel syndrome. BMC Microbiol 2021, 21: 316.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Weng RX, Wei YX, Li YC, Xu X, Zhuang JB, Xu GY, et al. Folic acid attenuates chronic visceral pain by reducing clostridiales abundance and hydrogen sulfide production. Mol Pain 2023, 19: 17448069221149834.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Kim YS, Kim N. Sex-gender differences in irritable bowel syndrome. J Neurogastroenterol Motil 2018, 24: 544–558.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Brierley SM 3rd, Gebhart GF, Ashley Blackshaw L. Splanchnic and pelvic mechanosensory afferents signal different qualities of colonic stimuli in mice. Gastroenterology 2004, 127: 166–178.

    Article  PubMed  Google Scholar 

  12. Bulbring E, Crema A. The release of 5-hydroxytryptamine in relation to pressure exerted on the intestinal mucosa. J Physiol 1959, 146: 18–28.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Bertrand PP. Real-time measurement of serotonin release and motility in Guinea pig ileum. J Physiol 2006, 577: 689–704.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

This research highlight was supported by grants from the National Natural Science Foundation of China (81920108016 and 32230041) and the Priority Academic Program Development of Jiangsu Higher Education Institutions of China.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Guang-Yin Xu.

Ethics declarations

Conflict of interest

The funders had no role in the study design, data collection, and analysis, decision to publish, or preparation of the manuscript.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yu, Y., Li, YC., Zhang, FC. et al. Enterochromaffin Cell: Friend or Foe for Human Health?. Neurosci. Bull. 39, 1732–1734 (2023). https://doi.org/10.1007/s12264-023-01090-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12264-023-01090-1

Navigation