Skip to main content
SpringerLink
Log in

Chemogenetic Therapeutics: A Powerful Tool to Control Cortical Seizures in Non-human Primates

  • Research Highlight
  • Published:
Neuroscience Bulletin Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Wang Y, Chen Z. An update for epilepsy research and antiepileptic drug development: Toward precise circuit therapy. Pharmacol Ther 2019, 201: 77–93.

    Article  CAS  PubMed  Google Scholar 

  2. McGonigal A. Frontal lobe seizures: Overview and update. J Neurol 2022, 269: 3363–3371.

    Article  PubMed  Google Scholar 

  3. Urban DJ, Roth BL. DREADDs (designer receptors exclusively activated by designer drugs): Chemogenetic tools with therapeutic utility. Annu Rev Pharmacol Toxicol 2015, 55: 399–417.

    Article  CAS  PubMed  Google Scholar 

  4. Krashes MJ. Resolving behavioral output via chemogenetic designer receptors exclusively activated by designer drugs. J Neurosci 2016, 36: 9268–9282.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Fei F, Wang X, Xu C, Shi J, Gong Y, Cheng H. Discrete subicular circuits control generalization of hippocampal seizures. Nat Commun 2022, 13: 5010.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Forcelli PA. Seizing control of neuronal activity: Chemogenetic applications in epilepsy. Epilepsy Curr 2022, 22: 303–308.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Chen B, Xu C, Wang Y, Lin W, Wang Y, Chen L, et al. A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy. Nat Commun 2020, 11: 923.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Miyakawa N, Nagai Y, Hori Y, Mimura K, Orihara A, Oyama K, et al. Chemogenetic attenuation of cortical seizures in nonhuman Primates. Nat Commun 2023, 14: 971.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Jensen KT, Harpaz NK, Dhawale AK, Wolff SBE, Ölveczky BP. Long-term stability of single neuron activity in the motor system. Nat Neurosci 2022, 25: 1664–1674.

    Article  CAS  PubMed  Google Scholar 

  10. Terrone G, Salamone A, Vezzani A. Inflammation and epilepsy: Preclinical findings and potential clinical translation. Curr Pharm Des 2017, 23: 5569–5576.

    Article  CAS  PubMed  Google Scholar 

  11. Yu J, Cheng Y, Cui Y, Zhai Y, Zhang W, Zhang M, et al. Anti-seizure and neuronal protective effects of irisin in kainic acid-induced chronic epilepsy model with spontaneous seizures. Neurosci Bull 2022, 38: 1347–1364.

    Article  CAS  PubMed  Google Scholar 

  12. Qiu Y, O’Neill N, Maffei B, Zourray C, Almacellas-Barbanoj A, Carpenter JC, et al. On-demand cell-autonomous gene therapy for brain circuit disorders. Science 2022, 378: 523–532.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Lai N, Cheng H, Li Z, Wang X, Ruan Y, Qi Y, et al. Interictal-period-activated neuronal ensemble in piriform cortex retards further seizure development. Cell Rep 2022, 41: 111798.

    Article  CAS  PubMed  Google Scholar 

  14. Reddy DS. Brain structural and neuroendocrine basis of sex differences in epilepsy. Handb Clin Neurol 2020, 175: 223–233.

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

This research highlight was supported by grants from the National Key R&D Program of China (2020YFA0803902), the National Natural Science Foundation of China (82022071), and the Natural Science Foundation of Zhejiang Province (LD22H310003).

Author information

Authors and Affiliations

  1. Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China

    Lin Yang, Mengdi Zhang, Yi Wang & Zhong Chen

  2. Zhejiang Rehabilitation Medical Center Department, The Third Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310013, China

    Yi Wang

  3. Epilepsy Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China

    Zhong Chen

Authors
  1. Lin Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mengdi Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yi Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Zhong Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Zhong Chen.

Ethics declarations

Conflict of interest

No conflicts to report.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yang, L., Zhang, M., Wang, Y. et al. Chemogenetic Therapeutics: A Powerful Tool to Control Cortical Seizures in Non-human Primates. Neurosci. Bull. 39, 1601–1604 (2023). https://doi.org/10.1007/s12264-023-01078-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12264-023-01078-x

Search

Navigation