Skip to main content
Log in

Hyperactivity of the Lateral Septum Leads to Hypersensitivity in Susceptible Mice

  • Research Highlight
  • Published:
Neuroscience Bulletin Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Golden SA, Covington HE III, Berton O, Russo SJ. A standardized protocol for repeated social defeat stress in mice. Nat Protoc 2011, 6: 1183–1191.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Li L, Durand-de Cuttoli R, Aubry AV, Burnett CJ, Cathomas F, Parise LF. Social trauma engages lateral septum circuitry to occlude social reward. Nature 2023, 613: 696–703.

    Article  CAS  PubMed  Google Scholar 

  3. Krishnan V, Han MH, Graham DL, Berton O, Renthal W, Russo SJ, et al. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 2007, 131: 391–404.

    Article  CAS  PubMed  Google Scholar 

  4. Yao Y, Gao G, Liu K, Shi X, Cheng M, Xiong Y, et al. Projections from D2 neurons in different subregions of nucleus accumbens shell to ventral Pallidum play distinct roles in reward and aversion. Neurosci Bull 2021, 37: 623–640.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Guzmán YF, Tronson NC, Jovasevic V, Sato K, Guedea AL, Mizukami H, et al. Fear-enhancing effects of septal oxytocin receptors. Nat Neurosci 2013, 16: 1185–1187.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Wang D, Pan X, Zhou Y, Wu Z, Ren K, Liu H, et al. Lateral septum-lateral hypothalamus circuit dysfunction in comorbid pain and anxiety. Mol Psychiatry 2023, 28: 1090–1100.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Chen Z, Chen G, Zhong J, Jiang S, Lai S, Xu H, et al. A circuit from lateral septum neurotensin neurons to tuberal nucleus controls hedonic feeding. Mol Psychiatry 2022, 27: 4843–4860.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Petrie KA, Schmidt D, Bubser M, Fadel J, Carraway RE, Deutch AY. Neurotensin activates GABAergic interneurons in the prefrontal cortex. J Neurosci 2005, 25: 1629–1636.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Chakraborty S, Kolling N, Walton ME, Mitchell AS. Critical role for the mediodorsal thalamus in permitting rapid reward-guided updating in stochastic reward environments. Elife 2016, 5: e13588.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Dudek KA, Dion-Albert L, Lebel M, LeClair K, Labrecque S, Tuck E, et al. Molecular adaptations of the blood-brain barrier promote stress resilience vs. depression. Proc Natl Acad Sci U S A 2020, 117: 3326–3336.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

This highlight article was supported by the National Natural Science Foundation of China (32100792 and 32200825), the Shandong Natural Science Foundation (ZR202111040168), and the Zhejiang Natural Science Foundation (LQ21C090003).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jie Li.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Qian, F., Zhang, X., Zhang, B. et al. Hyperactivity of the Lateral Septum Leads to Hypersensitivity in Susceptible Mice. Neurosci. Bull. 39, 1466–1468 (2023). https://doi.org/10.1007/s12264-023-01063-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12264-023-01063-4

Navigation