Skip to main content
Log in

Projections from the Prefrontal Cortex to Zona Incerta Mediate Fear Generalization

  • Letter to the Editor
  • Published:
Neuroscience Bulletin Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

References

  1. Ortiz S, Latsko MS, Fouty JL, Dutta S, Adkins JM, Jasnow AM. Anterior cingulate cortex and ventral hippocampal inputs to the basolateral amygdala selectively control generalized fear. J Neurosci 2019, 39: 6526–6539.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Zheng C, Huang Y, Bo B, Wei L, Liang Z, Wang Z. Projection from the anterior cingulate cortex to the lateral part of mediodorsal thalamus modulates vicarious freezing behavior. Neurosci Bull 2020, 36: 217–229.

    Article  PubMed  Google Scholar 

  3. Olsson KM, Meltendorf T, Fuge J, Kamp JC, Park DH, Richter MJ. Prevalence of mental disorders and impact on quality of life in patients with pulmonary arterial hypertension. Front Psychiatry 2021, 12: 667602.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Lv Y, Chen P, Shan QH, Qin XY, Qi XH, Zhou JN. Regulation of cued fear expression via corticotropin-releasing-factor neurons in the ventral anteromedial thalamic nucleus. Neurosci Bull 2021, 37: 217–228.

    Article  CAS  PubMed  Google Scholar 

  5. Zhao ZD, Chen Z, Xiang X, Hu M, Xie H, Jia X, et al. Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting. Nat Neurosci 2019, 22: 921–932.

    Article  CAS  PubMed  Google Scholar 

  6. Trageser JC, Burke KA, Masri R, Li Y, Sellers L, Keller A. State-dependent gating of sensory inputs by zona incerta. J Neurophysiol 2006, 96: 1456–1463.

    Article  PubMed  Google Scholar 

  7. Mitrofanis J, Ashkan K, Wallace BA, Benabid AL. Chemoarchitectonic heterogeneities in the primate zona incerta: Clinical and functional implications. J Neurocytol 2004, 33: 429–440.

    Article  PubMed  Google Scholar 

  8. Webler RD, Berg H, Fhong K, Tuominen L, Holt DJ, Morey RA, et al. The neurobiology of human fear generalization: Meta-analysis and working neural model. Neurosci Biobehav Rev 2021, 128: 421–436.

    Article  PubMed  Google Scholar 

  9. Zhou H, Xiong GJ, Jing L, Song NN, Pu DL, Tang X, et al. The interhemispheric CA1 circuit governs rapid generalisation but not fear memory. Nat Commun 2017, 8: 2190.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Roughley S, Marcus A, Killcross S. Dopamine D1 and D2 receptors are important for learning about neutral-valence relationships in sensory preconditioning. Front Behav Neurosci 2021, 15: 740992.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Jo YS, Heymann G, Zweifel LS. Dopamine neurons reflect the uncertainty in fear generalization. Neuron 2018, 100: 916-925.e3.

    Article  CAS  PubMed  Google Scholar 

  12. Wert-Carvajal C, Reneaux M, Tchumatchenko T, Clopath C. Dopamine and serotonin interplay for valence-based spatial learning. Cell Rep 2022, 39: 110645.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Zhou H, Xiang W, Huang M. Inactivation of zona incerta blocks social conditioned place aversion and modulates post-traumatic stress disorder-like behaviors in mice. Front Behav Neurosci 2021, 15: 743484.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Li Z, Rizzi G, Tan KR. Zona incerta subpopulations differentially encode and modulate anxiety. Sci Adv 2021, 7: eabf6709.

  15. Rozeske RR, Jercog D, Karalis N, Chaudun F, Khoder S, Girard D, et al. Prefrontal-periaqueductal gray-projecting neurons mediate context fear discrimination. Neuron 2018, 97: 898-910.e6.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported by grants from the National Natural Science Foundation of China (81870852 and 82171199), the Qing Lan Project of Jiangsu Province, the Education Department of Jiangsu Province (18KJA320007), the Natural Science Foundation of Jiangsu Province (BK20181146 and BK20210911), the Postgraduate Research & Practice Innovation Program of Jiangsu Province (KYCX21_2706, KYCX21_2703, and YCX21_2717), the Program on Basic Research Projects of Xuzhou City (KC21048), and the Special Funds for Anesthesia Medical Research of Jiangsu Medical Association SYH-32021-0040 (2021035).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Can Gao.

Ethics declarations

Conflict of interest

The authors declare that there are no conflicts of interest.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (PDF 610 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tong, K., Bu, GK., Jing, SQ. et al. Projections from the Prefrontal Cortex to Zona Incerta Mediate Fear Generalization. Neurosci. Bull. 39, 1151–1156 (2023). https://doi.org/10.1007/s12264-023-01046-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12264-023-01046-5

Navigation