Skip to main content

An Empathic Pain-Regulated Neural Circuit

Neuroscience Bulletin volume 38, pages 1613–1616 (2022)Cite this article

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

USD 39.95

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Fig. 1

References

  1. Langford DJ, Crager SE, Shehzad Z, Smith SB, Sotocinal SG, Levenstadt JS. Social modulation of pain as evidence for empathy in mice. Science 2006, 312: 1967–1970.

    Article  PubMed  CAS  Google Scholar 

  2. Du R, Luo WJ, Geng KW, Li CL, Yu Y, Wei N, et al. Empathic contagious pain and consolation in laboratory rodents: Species and sex comparisons. Neurosci Bull 2020, 36: 649–653.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Luo WJ, Li CL, Geng KW, Wang XL, Du R, Yu Y, et al. The similar past pain experience evokes both observational contagious pain and consolation in stranger rat observers. Neurosci Lett 2020, 722: 134840.

    Article  PubMed  CAS  Google Scholar 

  4. Lü YF, Yang Y, Li CL, Wang Y, Li Z, Chen J. The locus coeruleus-norepinephrine system mediates empathy for pain through selective up-regulation of P2X3 receptor in dorsal root Ganglia in rats. Front Neural Circuits 2017, 11: 66.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Li CL, Yu Y, He T, Wang RR, Geng KW, Du R, et al. Validating rat model of empathy for pain: Effects of pain expressions in social partners. Front Behav Neurosci 2018, 12: 242.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  6. Xiang Y, Wang Y, Gao S, Zhang X, Cui R. Neural mechanisms with respect to different paradigms and relevant regulatory factors in empathy for pain. Front Neurosci 2018, 12: 507.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Geng KW, Du R, Wei N, Li CL, Wang Y, Sun W, et al. Image-forming visual basis of empathy for pain in mice. Neurosci Bull 2020, 36: 1563–1569.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Smith ML, Asada N, Malenka RC. Anterior cingulate inputs to nucleus accumbens control the social transfer of pain and analgesia. Science 2021, 371: 153–159.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  9. Zhang MM, Geng AQ, Chen K, Wang J, Wang P, Qiu XT, et al. Glutamatergic synapses from the insular cortex to the basolateral amygdala encode observational pain. Neuron 2022, 110: 1993-2008.e6.

    Article  PubMed  CAS  Google Scholar 

  10. Kim S, Mátyás F, Lee S, Acsády L, Shin HS. Lateralization of observational fear learning at the cortical but not thalamic level in mice. Proc Natl Acad Sci U S A 2012, 109: 15497–15501.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  11. Chen J. Empathy for distress in humans and rodents. Neurosci Bull 2018, 34: 216–236.

    Article  PubMed  Google Scholar 

  12. Aaron RV, Fisher EA, de la Vega R, Lumley MA, Palermo TM. Alexithymia in individuals with chronic pain and its relation to pain intensity, physical interference, depression, and anxiety: A systematic review and meta-analysis. Pain 2019, 160: 994–1006.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

This highlight was supported by the Scientific Research Foundation for Scholars of HZNU (4125C5021920453 and 4125C50220204109).

Author information

Authors and Affiliations

  1. School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, China

    Xiumin Xue, Qian Wang, Zhihui Huang & Yongjie Wang

  2. Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, China

    Xiumin Xue, Qian Wang, Zhihui Huang & Yongjie Wang

Authors
  1. Xiumin Xue
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Qian Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Zhihui Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yongjie Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Zhihui Huang or Yongjie Wang.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Xue, X., Wang, Q., Huang, Z. et al. An Empathic Pain-Regulated Neural Circuit. Neurosci. Bull. 38, 1613–1616 (2022). https://doi.org/10.1007/s12264-022-00978-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12264-022-00978-8