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Specialized Microglia Resolve Neuropathic Pain in the Spinal Cord

Neuroscience Bulletin volume 39, pages 173–175 (2023)Cite this article

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References

  1. Finnerup NB, Kuner R, Jensen TS. Neuropathic pain: From mechanisms to treatment. Physiol Rev 2021, 101: 259–301.

    Article  CAS  Google Scholar 

  2. Price TJ, Basbaum AI, Bresnahan J, Chambers JF, de Koninck Y, Edwards RR. Transition to chronic pain: Opportunities for novel therapeutics. Nat Rev Neurosci 2018, 19: 383–384.

    Article  CAS  Google Scholar 

  3. Kohno K, Shirasaka R, Yoshihara K, Mikuriya S, Tanaka K, Takanami K, et al. A spinal microglia population involved in remitting and relapsing neuropathic pain. Science 2022, 376: 86–90.

    Article  CAS  Google Scholar 

  4. Inoue K, Tsuda M. Microglia in neuropathic pain: Cellular and molecular mechanisms and therapeutic potential. Nat Rev Neurosci 2018, 19: 138–152.

    Article  CAS  Google Scholar 

  5. Chen G, Zhang YQ, Qadri YJ, Serhan CN, Ji RR. Microglia in pain: Detrimental and protective roles in pathogenesis and resolution of pain. Neuron 2018, 100: 1292–1311.

    Article  CAS  Google Scholar 

  6. Shemer A, Erny D, Jung S, Prinz M. Microglia plasticity during health and disease: An immunological perspective. Trends Immunol 2015, 36: 614–624.

    Article  CAS  Google Scholar 

  7. Rothhammer V, Borucki DM, Tjon EC, Takenaka MC, Chao CC, Ardura-Fabregat A, et al. Microglial control of astrocytes in response to microbial metabolites. Nature 2018, 557: 724–728.

    Article  CAS  Google Scholar 

  8. Sideris-Lampretsas G, Malcangio M. Microglial heterogeneity in chronic pain. Brain Behav Immun 2021, 96: 279–289.

    Article  CAS  Google Scholar 

  9. Guan Z, Kuhn JA, Wang X, Colquitt B, Solorzano C, Vaman S, et al. Injured sensory neuron–derived CSF1 induces microglial proliferation and DAP12-dependent pain. Nat Neurosci 2016, 19: 94–101.

    Article  CAS  Google Scholar 

  10. Huang Y, Happonen KE, Burrola PG, O’Connor C, Hah N, Huang L, et al. Microglia use TAM receptors to detect and engulf amyloid β plaques. Nat Immunol 2021, 22: 586–594.

    Article  CAS  Google Scholar 

  11. Mogil JS. Qualitative sex differences in pain processing: Emerging evidence of a biased literature. Nat Rev Neurosci 2020, 21: 353–365.

    Article  CAS  Google Scholar 

  12. Krieger CC, Neumann S, Gershengorn MC. TSH/IGF1 receptor crosstalk: Mechanism and clinical implications. Pharmacol Ther 2020, 209: 107502.

    Article  CAS  Google Scholar 

  13. Tansley S, Uttam S, Ureña Guzmán A, Yaqubi M, Pacis A, Parisien M, et al. Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain. Nat Commun 2022, 13: 843.

    Article  CAS  Google Scholar 

  14. Niehaus JK, Taylor-Blake B, Loo L, Simon JM, Zylka MJ. Spinal macrophages resolve nociceptive hypersensitivity after peripheral injury. Neuron 2021, 109: 1274-1282.e6.

    Article  CAS  Google Scholar 

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Acknowledgements

This research highlight was supported by the National Key R&D Program of China (2021ZD0202703), Zhejiang Provincial Natural Science Foundation (LZ18C090002), and the National Natural Science Foundation of China (81971050 and 82171206).

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Authors and Affiliations

  1. Department of Anesthesiology and Department of Neurobiology of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China

    Jing Yang, Shulan Xie, Shengmei Zhu & Zhen-Zhong Xu

  2. NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain–Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, 310058, China

    Zhen-Zhong Xu

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  1. Jing Yang
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  2. Shulan Xie
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  3. Shengmei Zhu
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  4. Zhen-Zhong Xu
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Correspondence to Shengmei Zhu or Zhen-Zhong Xu.

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Yang, J., Xie, S., Zhu, S. et al. Specialized Microglia Resolve Neuropathic Pain in the Spinal Cord. Neurosci. Bull. 39, 173–175 (2023). https://doi.org/10.1007/s12264-022-00932-8

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  • DOI: https://doi.org/10.1007/s12264-022-00932-8