Skip to main content

Astrocyte-Mediated Myelin Phagocytosis in Ischemia

This is a preview of subscription content, access via your institution.

Fig. 1


  1. Chen D, Huang YC, Shi ZY, Li JY, Zhang Y, Wang K. Demyelinating processes in aging and stroke in the central nervous system and the prospect of treatment strategy. CNS Neurosci Ther 2020, 26: 1219–1229.

    Article  Google Scholar 

  2. Traiffort E, Kassoussi A, Zahaf A, Laouarem Y. Astrocytes and microglia as major players of myelin production in normal and pathological conditions. Front Cell Neurosci 2020, 14: 79.

    Article  CAS  Google Scholar 

  3. Neumann H, Kotter MR, Franklin RJM. Debris clearance by microglia: An essential link between degeneration and regeneration. Brain 2009, 132: 288–295.

    Article  CAS  Google Scholar 

  4. Wan T, Zhu WS, Zhao Y, Zhang XH, Ye RD, Zuo M, et al. Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice. Nat Commun 2022, 13: 1134.

    Article  CAS  Google Scholar 

  5. Gonias SL. Mechanisms by which LRP1 (low-density lipoprotein receptor-related protein-1) maintains arterial integrity. Arterioscler Thromb Vasc Biol 2018, 38: 2548–2549.

    Article  CAS  Google Scholar 

  6. Yang LD, Wu CY, Parker E, Li Y, Dong Y, Tucker L, et al. Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model. Theranostics 2022, 12: 2205–2231.

    Article  CAS  Google Scholar 

  7. Witte ME, Mahad DJ, Lassmann H, van Horssen J. Mitochondrial dysfunction contributes to neurodegeneration in multiple sclerosis. Trends Mol Med 2014, 20: 179–187.

    Article  Google Scholar 

  8. Wu CY, Yang LD, Youngblood H, Liu TCY, Duan R. Microglial SIRPα deletion facilitates synapse loss in preclinical models of neurodegeneration. Neurosci Bull 2022, 38: 232–234.

    Article  CAS  Google Scholar 

  9. Mills EA, Davis CHO, Bushong EA, Boassa D, Kim KY, Ellisman MH, et al. Astrocytes phagocytose focal dystrophies from shortening myelin segments in the optic nerve of Xenopus laevis at metamorphosis. Proc Natl Acad Sci U S A 2015, 112: 10509–10514.

    Article  CAS  Google Scholar 

  10. Xing CH, Wang XS, Cheng CJ, Montaner J, Mandeville E, Leung W, et al. Neuronal production of lipocalin-2 as a help-me signal for glial activation. Stroke 2014, 45: 2085–2092.

    Article  CAS  Google Scholar 

Download references


This highlight was supported by a grant from the National Institute of Aging, National Institutes of Health (1RF1AG058603).

Author information

Authors and Affiliations


Corresponding author

Correspondence to Quanguang Zhang.

Ethics declarations

Conflict of interest

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Yang, L., Zhang, D. & Zhang, Q. Astrocyte-Mediated Myelin Phagocytosis in Ischemia. Neurosci. Bull. 39, 167–169 (2023).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: