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Insula and the Immune System: More than mere Co-existence?

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  1. Reardon C, Murray K, Lomax AE. Neuroimmune communication in health and disease. Physiol Rev 2018, 98: 2287–2316.

    Article  CAS  Google Scholar 

  2. Eyo UB, Wu LJ. Microglia: Lifelong patrolling immune cells of the brain. Prog Neurobiol 2019, 179: 101614.

    Article  CAS  Google Scholar 

  3. Schiller M, Ben-Shaanan TL, Rolls A. Neuronal regulation of immunity: Why, how and where? Nat Rev Immunol 2021, 21: 20–36.

    Article  CAS  Google Scholar 

  4. Ramírez-Amaya V, Alvarez-Borda B, Ormsby CE, Martínez RD, Pérez-Montfort R, Bermúdez-Rattoni F. Insular cortex lesions impair the acquisition of conditioned immunosuppression. Brain Behav Immun 1996, 10: 103–114.

    Article  Google Scholar 

  5. Koren T, Yifa R, Amer M, Krot M, Boshnak N, Ben-Shaanan TL. Insular cortex neurons encode and retrieve specific immune responses. Cell 2021, 184: 5902-5915.e17.

    Article  CAS  Google Scholar 

  6. Kraynak TE, Marsland AL, Wager TD, Gianaros PJ. Functional neuroanatomy of peripheral inflammatory physiology: a meta-analysis of human neuroimaging studies. Neurosci Biobehav Rev 2018, 94: 76–92.

    Article  Google Scholar 

  7. Månsson KNT, Lasselin J, Karshikoff B, Axelsson J, Engler H, Schedlowski M, et al. Anterior Insula morphology and vulnerability to psychopathology-related symptoms in response to acute inflammation. Brain Behav Immun 2022, 99: 9–16.

    Article  CAS  Google Scholar 

  8. Harrison NA, Cooper E, Dowell NG, Keramida G, Voon V, Critchley HD, et al. Quantitative magnetization transfer imaging as a biomarker for effects of systemic inflammation on the brain. Biol Psychiatry 2015, 78: 49–57.

    Article  Google Scholar 

  9. Allman JM, Tetreault NA, Hakeem AY, Manaye KF, Semendeferi K, Erwin JM, et al. The von Economo neurons in frontoinsular and anterior cingulate cortex in great apes and humans. Brain Struct Funct 2010, 214: 495–517.

    Article  Google Scholar 

  10. Craig AD. Interoception: the sense of the physiological condition of the body. Curr Opin Neurobiol 2003, 13: 500–505.

    Article  CAS  Google Scholar 

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Correspondence to Panagiotis Kerezoudis.

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Kerezoudis, P., Howe, C.L., Wu, LJ. et al. Insula and the Immune System: More than mere Co-existence?. Neurosci. Bull. 38, 1271–1273 (2022).

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