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Microglia-Mediated Aβ Propagation in Alzheimer’s Disease

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  1. Wu CY, Yang LD, Tucker D, Dong Y, Zhu L, Duan R. Beneficial effects of exercise pretreatment in a sporadic Alzheimer’s rat model. Med Sci Sports Exerc 2018, 50: 945–956.

    Article  Google Scholar 

  2. Navarro V, Sanchez-Mejias E, Jimenez S, Muñoz-Castro C, Sanchez-Varo R, Davila JC, et al. Microglia in Alzheimer’s disease: Activated, dysfunctional or degenerative. Front Aging Neurosci 2018, 10: 140.

    Article  CAS  Google Scholar 

  3. Wu CY, Yang LD, Youngblood H, Liu TCY, Duan R. Microglial SIRPα deletion facilitates synapse loss in preclinical models of neurodegeneration. Neurosci Bull 2022, 38: 232–234.

    Article  CAS  Google Scholar 

  4. Bohlen CJ, Friedman BA, Dejanovic B, Sheng M. Microglia in brain development, homeostasis, and neurodegeneration. Annu Rev Genet 2019, 53: 263–288.

    Article  CAS  Google Scholar 

  5. Lai AY, McLaurin J. Clearance of amyloid-β peptides by microglia and macrophages: The issue of what, when and where. Future Neurol 2012, 7: 165–176.

    Article  CAS  Google Scholar 

  6. Fakhoury M. Microglia and astrocytes in Alzheimer’s disease: Implications for therapy. Curr Neuropharmacol 2018, 16: 508–518.

    Article  CAS  Google Scholar 

  7. Ziegler-Waldkirch S, D’Errico P, Sauer JF, Erny D, Savanthrapadian S, Loreth D, et al. Seed-induced Aβ deposition is modulated by microglia under environmental enrichment in a mouse model of Alzheimer’s disease. EMBO J 2018, 37: 167–182.

    Article  CAS  Google Scholar 

  8. Baik SH, Kang S, Son SM, Mook-Jung I. Microglia contributes to plaque growth by cell death due to uptake of amyloid β in the brain of Alzheimer’s disease mouse model. Glia 2016, 64: 2274–2290.

    Article  Google Scholar 

  9. d’Errico P, Ziegler-Waldkirch S, Aires V, Hoffmann P, Mezö C, Erny D, et al. Microglia contribute to the propagation of Aβ into unaffected brain tissue. Nat Neurosci 2022, 25: 20–25.

    Article  CAS  Google Scholar 

  10. Espuny-Camacho I, Arranz AM, Fiers M, Snellinx A, Ando K, Munck S, et al. Hallmarks of Alzheimer’s disease in stem-cell-derived human neurons transplanted into mouse brain. Neuron 2017, 93: 1066-1081.e8.

    Article  CAS  Google Scholar 

  11. Yang LD, Dong Y, Wu CY, Youngblood H, Li Y, Zong XM, et al. Effects of prenatal photobiomodulation treatment on neonatal hypoxic ischemia in rat offspring. Theranostics 2021, 11: 1269–1294.

    Article  CAS  Google Scholar 

  12. Domercq M, Vázquez-Villoldo N, Matute C. Neurotransmitter signaling in the pathophysiology of microglia. Front Cell Neurosci 2013, 7: 49.

    PubMed  PubMed Central  CAS  Google Scholar 

  13. Janelsins MC, Mastrangelo MA, Oddo S, LaFerla FM, Federoff HJ, Bowers WJ. Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer’s disease mice. J Neuroinflammation 2005, 2: 23.

    Article  CAS  Google Scholar 

  14. McAlpine CS, Park J, Griciuc A, Kim E, Choi SH, Iwamoto Y, et al. Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease. Nature 2021, 595: 701–706.

    Article  CAS  Google Scholar 

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This highlight was supported by the National Natural Science Foundation of China (32100918) and the Sigma Xi Grants in Aid of Research program (G03152021115804390).

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Correspondence to Luodan Yang.

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Yang, L., Feng, S., Wu, C. et al. Microglia-Mediated Aβ Propagation in Alzheimer’s Disease. Neurosci. Bull. 38, 1274–1276 (2022).

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