Skip to main content

Fundamental Neurocircuit of Anti-inflammatory Effect by Electroacupuncture Stimulation Identified

This is a preview of subscription content, access via your institution.

Fig. 1


  1. Lima FA, Ferreira LE, Pace FH. Acupuncture effectiveness as a complementary therapy in functional dyspepsia patients. Arq Gastroenterol 2013, 50: 202–207.

    Article  Google Scholar 

  2. Ma QF. Somato-autonomic reflexes of acupuncture. Med Acupunct 2020, 32: 362–366.

    Article  Google Scholar 

  3. Liu SB, Wang ZF, Su YS, Ray RS, Jing XH, Wang YQ. Somatotopic organization and intensity dependence in driving distinct NPY-expressing sympathetic pathways by electroacupuncture. Neuron 2020, 108: 436-450.e7.

    CAS  Article  Google Scholar 

  4. Zhao ZQ. Neural mechanism underlying acupuncture analgesia. Prog Neurobiol 2008, 85: 355–375.

    Article  Google Scholar 

  5. Liu SB, Wang ZF, Su YS, Qi L, Yang W, Fu MZ, et al. A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis. Nature 2021, 598: 641–645.

    CAS  Article  Google Scholar 

  6. Sato A. Neural mechanisms of autonomic responses elicited by somatic sensory stimulation. Neurosci Behav Physiol 1997, 27: 610–621.

    CAS  Article  Google Scholar 

  7. Okusa MD, Rosin DL, Tracey KJ. Targeting neural reflex circuits in immunity to treat kidney disease. Nat Rev Nephrol 2017, 13: 669–680.

    CAS  Article  Google Scholar 

  8. Ulloa L, Quiroz-Gonzalez S, Torres-Rosas R. Nerve stimulation: Immunomodulation and control of inflammation. Trends Mol Med 2017, 23: 1103–1120.

    Article  Google Scholar 

  9. Lim HD, Kim MH, Lee CY, Namgung U. Anti-inflammatory effects of acupuncture stimulation via the vagus nerve. PLoS One 2016, 11: e0151882.

  10. Su YS, He W, Wang C, Shi H, Zhao YF, Xin JJ, et al. “Intensity-response” effects of electroacupuncture on gastric motility and its underlying peripheral neural mechanism. Evid Based Complement Alternat Med 2013, 2013: 535742.

  11. Chon TY, Mallory MJ, Yang J, Bublitz SE, Do A, Dorsher PT. Laser acupuncture: A concise review. Med Acupunct 2019, 31: 164–168.

    Article  Google Scholar 

  12. Huo R, Han SP, Liu FY, Shou XJ, Liu LY, Song TJ, et al. Responses of primary afferent fibers to acupuncture-like peripheral stimulation at different frequencies: Characterization by single-unit recording in rats. Neurosci Bull 2020, 36: 907–918.

    CAS  Article  Google Scholar 

Download references


This Research Highlight was supported by National Natural Science Foundation of China (82102938), Zhejiang Public Welfare Technology Application Research Project (LGF19H080006, LGF21H010008, and LGF20H080005), Medical and Health Science and Technology Project of Zhejiang Province (2021KY842, 2021KY483, 2021KY077, 2022KY503, 2022KY046, 2022KY236, and 2022KY074), and Outstanding Youth Foundation of Zhejiang Provincial People's Hospital (ZRY2020B001).

Author information

Authors and Affiliations


Corresponding author

Correspondence to Ying Wang.

Ethics declarations

Conflict of interest

The authors declare that there is no conflict of interest.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Hu, J., Hu, W., Tang, L. et al. Fundamental Neurocircuit of Anti-inflammatory Effect by Electroacupuncture Stimulation Identified. Neurosci. Bull. 38, 837–839 (2022).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: