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Exclusion and Co-expression of Aversive Olfactory Long-Term Memories in Drosophila

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  1. Tully T, Preat T, Boynton SC, Vecchio MD. Genetic dissection of consolidated memory in Drosophila. Cell 1994, 79: 35–47.

    CAS  Article  Google Scholar 

  2. McBride SM, Giuliani G, Choi C, Krause P, Correale D, Watson K. Mushroom body ablation impairs short-term memory and long-term memory of courtship conditioning in Drosophila melanogaster. Neuron 1999, 24: 967–977.

    CAS  Article  Google Scholar 

  3. Krashes MJ, Waddell S. Rapid consolidation to a radish and protein synthesis-dependent long-term memory after single-session appetitive olfactory conditioning in Drosophila. J Neurosci 2008, 28: 3103–3113.

    CAS  Article  Google Scholar 

  4. Hirano Y, Masuda T, Naganos S, Matsuno M, Ueno K, Miyashita T, et al. Fasting launches CRTC to facilitate long-term memory formation in Drosophila. Science 2013, 339: 443–446.

    CAS  Article  Google Scholar 

  5. Zhao BH, Sun JM, Zhang XC, Mo H, Niu YJ, Li Q, et al. Long-term memory is formed immediately without the need for protein synthesis-dependent consolidation in Drosophila. Nat Commun 2019, 10: 4550.

    Article  Google Scholar 

  6. Zhao BH, Sun JM, Li Q, Zhong Y. Differential conditioning produces merged long-term memory in Drosophila. eLife 2021, 10: e66499.

    CAS  Article  Google Scholar 

  7. Sabandal JM, Berry JA, Davis RL. Dopamine-based mechanism for transient forgetting. Nature 2021, 591: 426–430.

    CAS  Article  Google Scholar 

  8. Godden DR, Baddeley AD. Context-dependent memory in two natural environments: On land and underwater. Br J Psychol 1975, 66: 325–331.

    Article  Google Scholar 

  9. Butler J, Rovee-Collier C. Contextual gating of memory retrieval. Dev Psychobiol 1989, 22: 533–552.

    CAS  Article  Google Scholar 

  10. Isabel G, Pascual A, Preat T. Exclusive consolidated memory phases in Drosophila. Science 2004, 304: 1024–1027.

    CAS  Article  Google Scholar 

  11. Kitamoto T. Conditional modification of behavior in Drosophila by targeted expression of a temperature-sensitive shibire allele in defined neurons. J Neurobiol 2001, 47: 81–92.

    CAS  Article  Google Scholar 

  12. Li Q, Zhang XC, Hu WT, Liang XT, Zhang F, Wang LZ, et al. Importin-7 mediates memory consolidation through regulation of nuclear translocation of training-activated MAPK in Drosophila. Proc Natl Acad Sci U S A 2016, 113: 3072–3077.

    CAS  Article  Google Scholar 

  13. Huang C, Zheng XG, Zhao H, Li M, Wang PZ, Xie ZY, et al. A permissive role of mushroom body α/β core neurons in long-term memory consolidation in Drosophila. Curr Biol 2012, 22: 1981–1989.

    CAS  Article  Google Scholar 

  14. Jacob PF, Waddell S. Spaced training forms complementary long-term memories of opposite valence in Drosophila. Neuron 2020, 106: 977-991.e4.

    CAS  Article  Google Scholar 

  15. Chen CC, Lin HW, Feng KL, Jhang RY, Chen LY, de Belle JS, et al. CREB repressor in mushroom body enhances Drosophila LTM formation. bioRxiv 2021,

    Article  PubMed  PubMed Central  Google Scholar 

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This work was supported by grants from the National Science Foundation of China (31970955) and the Tsinghua-Peking Center for Life Sciences.

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Correspondence to Qian Li.

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Zhao, B., Zhang, X., Zhao, J. et al. Exclusion and Co-expression of Aversive Olfactory Long-Term Memories in Drosophila. Neurosci. Bull. 38, 657–660 (2022).

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