Skip to main content
SpringerLink
Log in

Microglial SIRPα Deletion Facilitates Synapse Loss in Preclinical Models of Neurodegeneration

  • Research Highlight
  • Published:
Neuroscience Bulletin Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Grassivaro F, Menon R, Acquaviva M, Ottoboni L, Ruffini F, Bergamaschi A. Convergence between microglia and peripheral macrophages phenotype during development and neuroinflammation. J Neurosci 2020, 40: 784–795.

    Article  CAS  Google Scholar 

  2. Duveau A, Bertin E, Boué-Grabot E. Implication of neuronal versus microglial P2X4 receptors in central nervous system disorders. Neurosci Bull 2020, 36: 1327–1343.

    Article  CAS  Google Scholar 

  3. Sakai J. Core Concept: How synaptic pruning shapes neural wiring during development and possibly, in disease. Proc Natl Acad Sci U S A 2020, 117: 16096–16099.

    Article  CAS  Google Scholar 

  4. Hong S, Dissing-Olesen L, Stevens B. New insights on the role of microglia in synaptic pruning in health and disease. Curr Opin Neurobiol 2016, 36: 128–134.

    Article  CAS  Google Scholar 

  5. Bartels T, de Schepper S, Hong S. Microglia modulate neurodegeneration in Alzheimer’s and Parkinson’s diseases. Science 2020, 370: 66–69.

    Article  CAS  Google Scholar 

  6. Scott-Hewitt N, Perrucci F, Morini R, Erreni M, Mahoney M, Witkowska A, et al. Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia. EMBO J 2020, 39: e105380. https://doi.org/10.15252/embj.2020105380.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Lehrman EK, Wilton DK, Litvina EY, Welsh CA, Chang ST, Frouin A, et al. CD47 protects synapses from excess microglia-mediated pruning during development. Neuron 2018, 100: 120-134.e6.

    Article  CAS  Google Scholar 

  8. Rivest S. A “don’t eat me” immune signal protects neuronal connections. Nature 2018, 563: 42–43.

    Article  CAS  Google Scholar 

  9. Ding X, Wang J, Huang MX, Chen ZP, Liu J, Zhang QP, et al. Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration. Nat Commun 2021, 12: 2030.

    Article  CAS  Google Scholar 

  10. Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li SM, Ramakrishnan S, et al. Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science 2016, 352: 712–716.

    Article  CAS  Google Scholar 

  11. Zhang HY, Li FW, Yang YY, Chen J, Hu XM. SIRP/CD47 signaling in neurological disorders. Brain Res 2015, 1623: 74–80.

    Article  CAS  Google Scholar 

  12. Sellgren CM, Gracias J, Watmuff B, Biag JD, Thanos JM, Whittredge PB, et al. Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning. Nat Neurosci 2019, 22: 374–385.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This research highlight was supported by the National Key Research and Development Program of China (2017YFB0403801), the National Natural Science Foundation of China (31971096 and 31771256) and the Sigma Xi Grants in Aid of Research (GIAR) program (G03152021115804390). We would like to acknowledge Dr. Lorelei Tucker from Augusta University for helping edit our manuscript.

Author information

Author notes

  1. Chongyun Wu and Luodan Yang have contributed equally to this work.

Authors and Affiliations

  1. Laboratory of Regenerative Medicine in Sports Science, School of Physical Education and Sports Science, South China Normal University, Guangzhou, 510006, China

    Chongyun Wu, Timon Cheng-Yi Liu & Rui Duan

  2. Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA

    Luodan Yang

  3. Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA

    Hannah Youngblood

Authors
  1. Chongyun Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Luodan Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hannah Youngblood
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Timon Cheng-Yi Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Rui Duan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rui Duan.

Ethics declarations

Conflict of interest

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wu, C., Yang, L., Youngblood, H. et al. Microglial SIRPα Deletion Facilitates Synapse Loss in Preclinical Models of Neurodegeneration. Neurosci. Bull. 38, 232–234 (2022). https://doi.org/10.1007/s12264-021-00795-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12264-021-00795-5

Search

Navigation