Skip to main content

Astrocyte-derived ATP: A New Etiological Factor for Autism Spectrum Disorder

This is a preview of subscription content, access via your institution.

Fig. 1


  1. 1.

    Illes P, Burnstock G, Tang Y. Astroglia-derived ATP modulates CNS neuronal circuits. Trends Neurosci 2019, 42: 885–898.

    CAS  Article  Google Scholar 

  2. 2.

    Burnstock G, Krügel U, Abbracchio MP, Illes P. Purinergic signalling: From normal behaviour to pathological brain function. Prog Neurobiol 2011, 95: 229–274.

    CAS  Article  Google Scholar 

  3. 3.

    Huang Z, Xie N, Illes P, Di Virgilio F, Ulrich H, Semyanov A, et al. From purines to purinergic signalling: Molecular functions and human diseases. Signal Transduct Target Ther 2021, 6: 162.

    CAS  Article  Google Scholar 

  4. 4.

    Lord C, Brugha TS, Charman T, Cusack J, Dumas G, Frazier T, et al. Autism spectrum disorder. Nat Rev Dis Primers 2020, 6: 5.

    Article  Google Scholar 

  5. 5.

    Wang Q, Kong Y, Wu DY, Liu JH, Jie W, You QL, et al. Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice. Nat Commun 2021, 12: 3321.

    CAS  Article  Google Scholar 

  6. 6.

    Cao X, Li LP, Wang Q, Wu Q, Hu HH, Zhang M, et al. Astrocyte-derived ATP modulates depressive-like behaviors. Nat Med 2013, 19: 773–777.

    CAS  Article  Google Scholar 

  7. 7.

    Illes P, Verkhratsky A, Tang Y. Pathological ATPergic signaling in major depression and bipolar disorder. Front Mol Neurosci 2019, 12: 331.

    CAS  Article  Google Scholar 

  8. 8.

    Horváth G, Otrokocsi L, Beko K, Baranyi M, Kittel Á, Fritz-Ruenes PA, et al. P2X7 receptors drive poly (I: C) induced autism-like behavior in mice. J Neurosci 2019, 39: 2542–2561.

    PubMed  PubMed Central  Google Scholar 

  9. 9.

    Yu X, Taylor AMW, Nagai J, Golshani P, Evans CJ, Coppola G, et al. Reducing astrocyte calcium signaling in vivo alters striatal microcircuits and causes repetitive behavior. Neuron 2018, 99: 1170-1187.e9.

    CAS  Article  Google Scholar 

  10. 10.

    Manoli DS, State MW. Autism spectrum disorder genetics and the search for pathological mechanisms. Am J Psychiatry 2021, 178: 30–38.

    Article  Google Scholar 

Download references


This Research Highlight was supported by a generous grant (“The project First-Class Disciplines Development”; CZYHW1901) of the Chengdu University of Traditional Chinese Medicine in order to build up the “International Collaborative Centre on Big Science Plan for Purinergic Signalling” and grants of the State Administration of Foreign Experts Affairs to support the stay of PR and PI in Chengdu (G20190236012), and Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (ZYYCXTD-D-202003), Sichuan Science and Technology Program (2019YFH0108).

Author information



Corresponding authors

Correspondence to Yong Tang or Peter Illes.

Ethics declarations

Conflict of interest

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Li, J., Rubini, P., Tang, Y. et al. Astrocyte-derived ATP: A New Etiological Factor for Autism Spectrum Disorder. Neurosci. Bull. (2021).

Download citation