Skip to main content

Peripheral Delivery of Ganglioside GM1 Exacerbates the Pathogenesis of Alzheimer’s Disease in a Mouse Model

This is a preview of subscription content, access via your institution.

Fig. 1
Fig. 2


  1. 1.

    Busche MA, Hyman BT. Synergy between amyloid-β and tau in Alzheimer’s disease. Nat Neurosci 2020, 23: 1183–1193.

    CAS  Article  Google Scholar 

  2. 2.

    Jiao SS, Yao XQ, Liu YH, Wang QH, Zeng F, Lu JJ. Edaravone alleviates Alzheimer’s disease-type pathologies and cognitive deficits. Proc Natl Acad Sci U S A 2015, 112: 5225–5230.

    CAS  Article  Google Scholar 

  3. 3.

    Candelise L, Ciccone A. Gangliosides for acute ischaemic stroke. Cochrane Database Syst Rev 2000: CD000094.

  4. 4.

    Hong S, Ostaszewski BL, Yang T, O’Malley TT, Jin M, Yanagisawa K, et al. Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes. Neuron 2014, 82: 308–319.

    CAS  Article  Google Scholar 

  5. 5.

    Zha Q, Ruan Y, Hartmann T, Beyreuther K, Zhang D. GM1 ganglioside regulates the proteolysis of amyloid precursor protein. Mol Psychiatry 2004, 9: 946–952.

    CAS  Article  Google Scholar 

  6. 6.

    Matsuoka Y, Saito M, LaFrancois J, Saito M, Gaynor K, Olm V, et al. Novel therapeutic approach for the treatment of Alzheimer’s disease by peripheral administration of agents with an affinity to beta-amyloid. J Neurosci 2003, 23: 29–33.

    CAS  Article  Google Scholar 

  7. 7.

    Okada T, Wakabayashi M, Ikeda K, Matsuzaki K. Formation of toxic fibrils of Alzheimer’s amyloid beta-protein-(1–40) by monosialoganglioside GM1, a neuronal membrane component. J Mol Biol 2007, 371: 481–489.

    CAS  Article  Google Scholar 

  8. 8.

    Zhang H, Ding J, Tian W, Wang L, Huang L, Ruan Y, et al. Ganglioside GM1 binding the N-Terminus of amyloid precursor protein. Neurobiol Aging 2009, 30: 1245–1253.

    Article  Google Scholar 

  9. 9.

    di Biase E, Lunghi G, Maggioni M, Fazzari M, Pomè DY, Loberto N, et al. GM1 oligosaccharide crosses the human blood–brain barrier in vitro by a paracellular route. Int J Mol Sci 2020, 21: 2858.

    CAS  Article  Google Scholar 

  10. 10.

    Choi BR, Cho WH, Kim J, Lee HJ, Chung C, Jeon WK, et al. Increased expression of the receptor for advanced glycation end products in neurons and astrocytes in a triple transgenic mouse model of Alzheimer’s disease. Exp Mol Med 2014, 46: e75.

    CAS  Article  Google Scholar 

  11. 11.

    Liu Y, Studzinski C, Beckett T, Guan H, Hersh MA, Murphy MP, et al. Expression of neprilysin in skeletal muscle reduces amyloid burden in a transgenic mouse model of Alzheimer disease. Mol Ther 2009, 17: 1381–1386.

    CAS  Article  Google Scholar 

  12. 12.

    Guo YL, Duan WJ, Lu DH, Ma XH, Li XX, Li Z, et al. Autophagy-dependent removal of α-synuclein: A novel mechanism of GM1 ganglioside neuroprotection against Parkinson’s disease. Acta Pharmacol Sin 2021, 42: 518–528.

    CAS  Article  Google Scholar 

  13. 13.

    Kracun I, Kalanj S, Talan-Hranilovic J, Cosovic C. Cortical distribution of gangliosides in Alzheimer’s disease. Neurochem Int 1992, 20: 433–438.

    CAS  Article  Google Scholar 

  14. 14.

    Ala T, Romero S, Knight F, Feldt K, Frey WH. GM-1 treatment of Alzheimer’s disease. A pilot study of safety and efficacy. JAMA Neurol 1990, 47: 1126–1130.

    CAS  Google Scholar 

  15. 15.

    Flicker C, Ferris SH, Kalkstein D, Serby M. A double-blind, placebo-controlled crossover study of ganglioside GM1 treatment for Alzheimer’s disease. Am J Psychiatry 1994, 151: 126–129.

    CAS  Article  Google Scholar 

Download references


This work was supported by the National Natural Science Foundation of China (81701046) and Chongqing Science and Technology Commission (cstc2018jcyjAX0664).

Author information



Corresponding authors

Correspondence to Zhi-Qiang Xu or Ye-Ran Wang.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (PDF 1582 kb)

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Yang, CC., Cheng, Y., Yang, HM. et al. Peripheral Delivery of Ganglioside GM1 Exacerbates the Pathogenesis of Alzheimer’s Disease in a Mouse Model. Neurosci. Bull. (2021).

Download citation