Skip to main content
SpringerLink
Log in

Lateral Habenula Serves as a Potential Therapeutic Target for Neuropathic Pain

  • Letter to the Editor
  • Published:
Neuroscience Bulletin Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Hikosaka O. The habenula: from stress evasion to value-based decision-making. Nat Rev Neurosci 2010, 11: 503–513.

    Article  CAS  Google Scholar 

  2. Benabid AL, Jeaugey L. Cells of the rat lateral habenula respond to high-threshold somatosensory inputs. Neurosci Lett 1989, 96: 289–294.

    Article  CAS  Google Scholar 

  3. Khalilzadeh E, Saiah GV. The possible mechanisms of analgesia produced by microinjection of morphine into the lateral habenula in the acute model of trigeminal pain in rats. Res Pharm Sci 2017, 12: 241–248.

    Article  Google Scholar 

  4. Shelton L, Becerra L, Borsook D. Unmasking the mysteries of the habenula in pain and analgesia. Prog Neurobiol 2012, 96: 208–219.

    Article  CAS  Google Scholar 

  5. Cui WQ, Zhang WW, Chen T, Li Q, Xu F, Mao-Ying QL. Tacr3 in the lateral habenula differentially regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia. Acta Neuropathol Commun 2020, 8: 44.

    Article  CAS  Google Scholar 

  6. Hu TT, Wang RR, Tang YY, Wu YX, Yu J, Hou WW, et al. TLR4 deficiency abrogated widespread tactile allodynia, but not widespread thermal hyperalgesia and trigeminal neuropathic pain after partial infraorbital nerve transection. Pain 2018, 159: 273–283.

    Article  CAS  Google Scholar 

  7. Lee DJ, Lozano CS, Dallapiazza RF, Lozano AM. Current and future directions of deep brain stimulation for neurological and psychiatric disorders. J Neurosurg 2019, 131: 333–342.

    Article  CAS  Google Scholar 

  8. Fuchs P, Cox VC. Habenula lesions attenuate lateral hypothalamic analgesia in the formalin test. Neuroreport 1993, 4: 121–124.

    Article  CAS  Google Scholar 

  9. Quina LA, Walker A, Morton G, Han V, Turner EE. GAD2 expression defines a class of excitatory lateral habenula neurons in mice that project to the raphe and pontine tegmentum. eNeuro 2020, 7: ENEURO.0527–19.2020.

  10. Edwards RR, Dworkin RH, Sullivan MD, Turk DC, Wasan AD. The role of psychosocial processes in the development and maintenance of chronic pain. J Pain 2016, 17: T70–T92.

    Article  Google Scholar 

  11. Ghasemi Z, Naderi N, Shojaei A, Raoufy MR, Ahmadirad N, Barkley V, et al. The inhibitory effect of different patterns of low frequency stimulation on neuronal firing following epileptiform activity in rat hippocampal slices. Brain Res 2019, 1706: 184–195.

    Article  CAS  Google Scholar 

  12. Ruan Y, Xu C, Lan J, Nao J, Zhang S, Fan F, et al. Low-frequency stimulation at the subiculum is anti-convulsant and anti-drug-resistant in a mouse model of lamotrigine-resistant temporal lobe epilepsy. Neurosci Bull 2020, 36: 654–658.

    Article  CAS  Google Scholar 

  13. Wilcox KS, Gutnick MJ, Christoph GR. Electrophysiological properties of neurons in the lateral habenula nucleus: an in vitro study. J Neurophysiol 1988, 59: 212–225.

    Article  CAS  Google Scholar 

  14. Li B, Piriz J, Mirrione M, Chung C, Proulx CD, Schulz D, et al. Synaptic potentiation onto habenula neurons in the learned helplessness model of depression. Nature 2011, 470: 535–539.

    Article  CAS  Google Scholar 

  15. Dandekar MP, Fenoy AJ, Carvalho AF, Soares JC, Quevedo J. Deep brain stimulation for treatment-resistant depression: an integrative review of preclinical and clinical findings and translational implications. Mol Psychiatry 2018, 23: 1094–1112.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by grants from National Natural Science Foundation of China (81872843, 81673404, and 81821091).

Author information

Author notes

  1. Yu Du, Yu-Xing Wu and Fang Guo have contributed equally to this work.

Authors and Affiliations

  1. Department of Pharmacology and Department of Anesthesiology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China

    Yu Du, Yu-Xing Wu, Fang Guo, Feng-Hui Qu, Ting-Ting Hu, Wei-Wei Hu & Shi-Hong Zhang

  2. Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China

    Ting-Ting Hu, Bei Tan, Yi Wang & Zhong Chen

Authors
  1. Yu Du
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yu-Xing Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Fang Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Feng-Hui Qu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ting-Ting Hu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Bei Tan
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yi Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Wei-Wei Hu
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Zhong Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Shi-Hong Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Zhong Chen or Shi-Hong Zhang.

Ethics declarations

Conflict of interest

All authors claim that there are no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Du, Y., Wu, YX., Guo, F. et al. Lateral Habenula Serves as a Potential Therapeutic Target for Neuropathic Pain. Neurosci. Bull. 37, 1339–1344 (2021). https://doi.org/10.1007/s12264-021-00728-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12264-021-00728-2

Search

Navigation