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An Evolved Human-specific Epigenetic Mechanism for Cortical Expansion and Gyrification

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References

  1. Lui JH, Hansen DV, Kriegstein AR. Development and evolution of the human neocortex. Cell 2011, 146: 18–36.

    Article  CAS  Google Scholar 

  2. Li QW, Wang LF, Ma YL, Yue WH, Zhang D, Li J. P-Rex1 overexpression results in aberrant neuronal polarity and psychosis-related behaviors. Neurosci Bull 2019, 35: 1011–1023.

    Article  CAS  Google Scholar 

  3. Namba T, Huttner WB. Neural progenitor cells and their role in the development and evolutionary expansion of the neocortex. Wiley Interdiscip Rev Dev Biol 2017, https://doi.org/10.1002/wdev.256.

    Article  PubMed  Google Scholar 

  4. Sun T, Hevner RF. Growth and folding of the mammalian cerebral cortex: From molecules to malformations. Nat Rev Neurosci 2014, 15: 217–232.

    Article  CAS  Google Scholar 

  5. Cárdenas A, Borrell V. Molecular and cellular evolution of corticogenesis in amniotes. Cell Mol Life Sci 2020, 77: 1435–1460.

    Article  Google Scholar 

  6. Hou QQ, Xiao Q, Sun XY, Ju XC, Luo ZG. TBC1D3 promotes neural progenitor proliferation by suppressing the histone methyltransferase G9a. Sci Adv 2021, 7: eaba8053.

    Article  CAS  Google Scholar 

  7. Stahl PD, Wainszelbaum MJ. Human-specific genes may offer a unique window into human cell signaling. Sci Signal 2009, 2: pe59.

    Article  Google Scholar 

  8. Ju XC, Hou QQ, Sheng AL, Wu KY, Zhou Y, Jin Y. The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice. Elife 2016, 5: e18197.

    Article  Google Scholar 

  9. Benevento M, van de Molengraft M, van Westen R, van Bokhoven H, Kasri NN. The role of chromatin repressive marks in cognition and disease: A focus on the repressive complex GLP/G9a. Neurobiol Learn Mem 2015, 124: 88–96.

    Article  CAS  Google Scholar 

  10. Kleefstra T, Smidt M, Banning MJ, Oudakker AR, van Esch H, de Brouwer AP, et al. Disruption of the gene Euchromatin Histone Methyl Transferase1 (Eu-HMTase1) is associated with the 9q34 subtelomeric deletion syndrome. J Med Genet 2005, 42: 299–306.

    Article  CAS  Google Scholar 

  11. Vedadi M, Barsyte-Lovejoy D, Liu F, Rival-Gervier S, Allali-Hassani A, Labrie V, et al. A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol 2011, 7: 566–574.

    Article  CAS  Google Scholar 

  12. Wainszelbaum MJ, Charron AJ, Kong C, Kirkpatrick DS, Srikanth P, Barbieri MA, et al. The hominoid-specific oncogene TBC1D3 activates Ras and modulates epidermal growth factor receptor signaling and trafficking. J Biol Chem 2008, 283: 13233–13242.

    Article  CAS  Google Scholar 

  13. Chenn A, Walsh CA. Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science 2002, 297: 365–369.

    Article  CAS  Google Scholar 

  14. Fiddes IT, Lodewijk GA, Mooring M, Bosworth CM, Ewing AD, Mantalas GL, et al. Human-specific NOTCH2NL genes affect notch signaling and cortical neurogenesis. Cell 2018, 173: 1356-1369.e22.

    Article  CAS  Google Scholar 

  15. Suzuki IK, Gacquer D, Van Heurck R, Kumar D, Wojno M, Bilheu A, et al. Human-specific NOTCH2NL genes expand cortical neurogenesis through delta/notch regulation. Cell 2018, 173: 1370-1384.e16.

    Article  CAS  Google Scholar 

  16. di Lullo E, Kriegstein AR. The use of brain organoids to investigate neural development and disease. Nat Rev Neurosci 2017, 18: 573–584.

    Article  Google Scholar 

Download references

Acknowledgements

This Research Highlight was supported by the National Key Research and Development Program of China (2018YFA0108000), the National Natural Science Foundation of China (31872763), Shanghai Municipal Science and Technology Major Project (2018SHZDZX01, 19JC1411003) and ZJLab.

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Authors and Affiliations

  1. Department of Anesthesia, The State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, and Zhongshan Hospital, Fudan University, Shanghai, 200032, China

    Dan Li & Yunli Xie

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  1. Dan Li
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  2. Yunli Xie
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Correspondence to Yunli Xie.

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Li, D., Xie, Y. An Evolved Human-specific Epigenetic Mechanism for Cortical Expansion and Gyrification. Neurosci. Bull. 37, 1370–1372 (2021). https://doi.org/10.1007/s12264-021-00719-3

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  • DOI: https://doi.org/10.1007/s12264-021-00719-3

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