Autologous Transplantation for Parkinson's Disease Patients: Feasibility and Challenge

This is a preview of subscription content, access via your institution.


  1. 1.

    Li T, Le W. Biomarkers for Parkinson’s disease: How good are they? Neurosci Bull 2020, 36: 183–194.

    Article  Google Scholar 

  2. 2.

    Dong D, Xie J, Wang J. Neuroprotective effects of brain-gut peptides: a potential therapy for Parkinson’s disease. Neurosci Bull 2019, 35: 1085–1096.

    Article  Google Scholar 

  3. 3.

    Feigin VL, Nichols E, Alam T, Bannick MS, Beghi E, Blake N. Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 2019, 18: 459–480.

    Article  Google Scholar 

  4. 4.

    Armstrong MJ, Okun MS. Diagnosis and treatment of Parkinson disease: a review. JAMA 2020, 323: 548–560.

    Article  Google Scholar 

  5. 5.

    Schweitzer JS, Song B, Herrington TM, Park TY, Lee N, Ko S, et al. Personalized iPSC-derived dopamine progenitor cells for Parkinson’s disease. N Engl J Med 2020, 382: 1926–1932.

    CAS  Article  Google Scholar 

  6. 6.

    Song B, Cha Y, Ko S, Jeon J, Lee N, Seo H, et al. Human autologous iPSC-derived dopaminergic progenitors restore motor function in Parkinson’s disease models. J Clin Invest 2020, 130: 904–920.

    CAS  Article  Google Scholar 

  7. 7.

    Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131: 861–872.

    CAS  Article  Google Scholar 

  8. 8.

    Kriks S, Shim JW, Piao J, Ganat YM, Wakeman DR, Xie Z, et al. Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease. Nature 2011, 480: 547–551.

    CAS  Article  Google Scholar 

  9. 9.

    Kikuchi T, Morizane A, Doi D, Magotani H, Onoe H, Hayashi T, et al. Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model. Nature 2017, 548: 592–596.

    CAS  Article  Google Scholar 

  10. 10.

    Lindvall O. Balancing expectations for success in stem cell-based clinical trials for Parkinson’s disease. Cell Stem Cell 2020, 27: 519–522.

    CAS  Article  Google Scholar 

Download references


This highlight article was supported by National Key R&D Program of China (2017YFA0105000), the National Natural Science Foundation of China (U1904207, 81530037, 91849115, and 82001973), the Provincial and Ministry of Health Construction Committee of Henan Province (SBGJ2020003017), and the Excellent Youth Foundation of Henan Health Commission.

Author information



Corresponding author

Correspondence to Yuming Xu.

Ethics declarations

Conflict of interest

The authors claim that there are no conflicts of interest.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Zhang, Q., Wang, Y., Wang, Y. et al. Autologous Transplantation for Parkinson's Disease Patients: Feasibility and Challenge. Neurosci. Bull. 37, 1085–1086 (2021).

Download citation