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Naturally Occurring Parkinson’s Disease Raises the Need for Nonhuman Primates in Neurodegenerative Diseases Research

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  1. 1.

    Poewe W, Seppi K, Tanner CM, Halliday GM, Brundin P, Volkmann J, et al. Parkinson disease. Nat Rev Dis Primers 2017, 3: 17013.

    Article  Google Scholar 

  2. 2.

    Dawson TM, Ko HS, Dawson VL. Genetic animal models of Parkinson’s disease. Neuron 2010, 66: 646–661.

    CAS  Article  Google Scholar 

  3. 3.

    Diederich NJ, James Surmeier D, Uchihara T, Grillner S, Goetz CG. Parkinson’s disease: Is it a consequence of human brain evolution? Mov Disord 2019, 34: 453–459.

    Article  Google Scholar 

  4. 4.

    Yang W, Liu Y, Tu Z, Xiao C, Yan S, Ma X, et al. CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys. Cell Res 2019, 29: 334–336.

    CAS  Article  Google Scholar 

  5. 5.

    Li H, Su LY, Yang LX, Li M, Liu QJ, Li ZH, et al. A cynomolgus monkey with naturally occurring Parkinson’s disease. Natl Sci Rev 2021, 8: nwaa292.

    Article  Google Scholar 

  6. 6.

    Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, et al. Reversing a model of Parkinson’s disease with in situ converted nigral neurons. Nature 2020, 582: 550–556.

    CAS  Article  Google Scholar 

  7. 7.

    Li TB, Le WD. Biomarkers for Parkinson’s disease: How good are they? Neurosci Bull 2020, 36: 183–194.

    Article  Google Scholar 

  8. 8.

    Glaser T, Andrejew R, Oliveira-Giacomelli Á, Ribeiro DE, Bonfim Marques L, Ye Q, et al. Purinergic receptors in basal Ganglia diseases: Shared molecular mechanisms between Huntington’s and Parkinson’s disease. Neurosci Bull 2020, 36: 1299–1314.

    Article  Google Scholar 

  9. 9.

    King A. The search for better animal models of Alzheimer’s disease. Nature 2018, 559: S13–S15.

    CAS  Article  Google Scholar 

  10. 10.

    Ning B, Zhao Y. To embrace open science more closely. The Innovation 2020, 1: 100012.

    Article  Google Scholar 

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This Research Highlight was supported by the National Natural Science Foundation of China (U20A2017), the Natural Science Foundation of Guangdong Province (2020A1515010785), the Youth Innovation Promotion Association CAS (2017120), and the Chinese Academy of Sciences International Partnership Program (172644KYSB20170004).

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Correspondence to Ji Dai.

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Yao, Y., Dai, J. Naturally Occurring Parkinson’s Disease Raises the Need for Nonhuman Primates in Neurodegenerative Diseases Research. Neurosci. Bull. 37, 1267–1269 (2021).

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