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Heteromolecular Plasticity in Striatal Astrocytes

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  1. 1.

    Allen NJ, Eroglu C. Cell biology of astrocyte-synapse interactions. Neuron 2017, 96: 697–708.

    CAS  Article  Google Scholar 

  2. 2.

    Khakh BS, Sofroniew MV. Diversity of astrocyte functions and phenotypes in neural circuits. Nat Neurosci 2015, 18: 942–952.

    CAS  Article  Google Scholar 

  3. 3.

    Hu NY, Chen YT, Wang Q, Jie W, Liu YS, You QL. Expression patterns of inducible cre recombinase driven by differential astrocyte-specific promoters in transgenic mouse lines. Neurosci Bull 2020, 36: 530–544.

    Article  Google Scholar 

  4. 4.

    Khakh BS, Deneen B. The emerging nature of astrocyte diversity. Annu Rev Neurosci 2019, 42: 187–207.

    CAS  Article  Google Scholar 

  5. 5.

    Bayraktar OA, Bartels T, Holmqvist S, Kleshchevnikov V, Martirosyan A, Polioudakis D, et al. Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map. Nat Neurosci 2020, 23: 500–509.

    CAS  Article  Google Scholar 

  6. 6.

    Yu X, Nagai J, Marti-Solano M, Soto JS, Coppola G, Babu MM, et al. Context-specific striatal astrocyte molecular responses are phenotypically exploitable. Neuron 2020, 108: 1146-1162.e10.

    Article  Google Scholar 

  7. 7.

    Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, et al. Neurotoxic reactive astrocytes are induced by activated microglia. Nature 2017, 541: 481–487.

    CAS  Article  Google Scholar 

  8. 8.

    Al-Dalahmah O, Sosunov AA, Shaik A, Ofori K, Liu Y, Vonsattel JP, et al. Single-nucleus RNA-seq identifies Huntington disease astrocyte states. Acta Neuropathol Commun 2020, 8: 19.

    CAS  Article  Google Scholar 

  9. 9.

    Yu X, Nagai J, Khakh BS. Improved tools to study astrocytes. Nat Rev Neurosci 2020, 21: 121–138.

    CAS  Article  Google Scholar 

  10. 10.

    Durkee CA, Covelo A, Lines J, Kofuji P, Aguilar J, Araque A. Gi/o protein-coupled receptors inhibit neurons but activate astrocytes and stimulate gliotransmission. Glia 2019, 67: 1076–1093.

    Article  Google Scholar 

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This Research Highlight was  supported by grants from the National Natural Science Foundation of China (31430032, 81329003, 81671356, 31801007 and 81881240049), the Program for Changjiang Scholars and Innovative Research Team in University (IRT_16R37), the Science and Technology Program of Guangdong Province, China (2018B030334001), Basic and Applied Basic Research Foundation of Guangdong Province, China (2020A1515011310), Science and Technology Program of Guangzhou Municipality (201707020027), Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence Fund (2019019).

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Correspondence to Tian-Ming Gao.

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Chen, YH., Gao, TM. Heteromolecular Plasticity in Striatal Astrocytes. Neurosci. Bull. 37, 1264–1266 (2021).

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