Breakthrough in Structural and Functional Dissection of the Hypothalamo-Neurohypophysial System

This is a preview of subscription content, access via your institution.

Fig. 1


  1. 1.

    Hashimoto H, Matsuura T, Ueta Y. Fluorescent visualization of oxytocin in the hypothalamo-neurohypophysial system. Front Neurosci 2014, 8: 213.

    Article  Google Scholar 

  2. 2.

    Antunes-Rodrigues J, de Castro M, Elias LL, Valenca MM, McCann SM. Neuroendocrine control of body fluid metabolism. Physiol Rev 2004, 84: 169–208.

    CAS  Article  Google Scholar 

  3. 3.

    Raggenbass M. Vasopressin- and oxytocin-induced activity in the central nervous system: electrophysiological studies using in-vitro systems. Prog Neurobiol 2001, 64: 307–326.

    CAS  Article  Google Scholar 

  4. 4.

    Hasan MT, Althammer F, Silva da Gouveia M, Goyon S, Eliava M, Lefevre A, et al. A fear memory engram and its plasticity in the hypothalamic oxytocin system. Neuron 2019, 103: 133–146 e138.

  5. 5.

    Meyer-Lindenberg A, Domes G, Kirsch P, Heinrichs M. Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine. Nat Rev Neurosci 2011, 12: 524–538.

    CAS  Article  Google Scholar 

  6. 6.

    Zhang B, Qiu L, Xiao W, Ni H, Chen L, Wang F. Reconstruction of the hypothalamo-neurohypophysial system and functional dissection of magnocellular oxytocin neurons in the brain. Neuron 2021, 109: 331–346. e7.

    Google Scholar 

  7. 7.

    Taniguchi Y, Yoshida M, Ishikawa K, Suzuki M, Kurosumi K. The distribution of vasopressin- or oxytocin-neurons projecting to the posterior pituitary as revealed by a combination of retrograde transport of horseradish peroxidase and immunohistochemistry. Arch Histol Cytol 1988, 51: 83–89.

    CAS  Article  Google Scholar 

  8. 8.

    Fisher AW, Price PG, Burford GD, Lederis K. A 3-dimensional reconstruction of the hypothalamo-neurohypophysial system of the rat. The neurons projecting to the neuro/intermediate lobe and those containing vasopressin and somatostatin. Cell Tissue Res 1979, 204: 343–354.

  9. 9.

    Eliava M, Melchior M, Knobloch-Bollmann HS, Wahis J, da Silva Gouveia M, Tang Y, et al. A New population of parvocellular oxytocin neurons controlling magnocellular neuron activity and inflammatory pain processing. Neuron 2016, 89: 1291–1304.

    CAS  Article  Google Scholar 

  10. 10.

    Swanson LW, Sawchenko PE. Hypothalamic integration: organization of the paraventricular and supraoptic nuclei. Annu Rev Neurosci 1983, 6: 269–324.

    CAS  Article  Google Scholar 

  11. 11.

    Armstrong WE, Warach S, Hatton GI, McNeill TH. Subnuclei in the rat hypothalamic paraventricular nucleus: a cytoarchitectural, horseradish peroxidase and immunocytochemical analysis. Neuroscience 1980, 5: 1931–1958.

    CAS  Article  Google Scholar 

  12. 12.

    Brunnlieb C, Nave G, Camerer CF, Schosser S, Vogt B, Munte TF, et al. Vasopressin increases human risky cooperative behavior. Proc Natl Acad Sci U S A 2016, 113: 2051–2056.

    CAS  Article  Google Scholar 

  13. 13.

    Zhang R, Zhang HF, Han JS, Han SP. Genes related to oxytocin and arginine-vasopressin pathways: associations with autism spectrum disorders. Neurosci Bull 2017, 33: 238–246.

    CAS  Article  Google Scholar 

Download references


This Highlight was supported by the National Natural Science Foundation of China (81830035 and 82003729).

Author information



Corresponding author

Correspondence to Ying Wang.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Wang, Y., Xu, H. & Zhang, X. Breakthrough in Structural and Functional Dissection of the Hypothalamo-Neurohypophysial System. Neurosci. Bull. 37, 1087–1089 (2021).

Download citation