Skip to main content

The Parabrachial Nucleus as a Key Regulator of Neuropathic Pain

This is a preview of subscription content, access via your institution.

Fig. 1


  1. Calvo M, Davies AJ, Hebert HL, Weir GA, Chesler EJ, Finnerup NB. The genetics of neuropathic pain from model organisms to clinical application. Neuron 2019, 104: 637–653.

    CAS  Article  Google Scholar 

  2. Wu XB, He LN, Jiang BC, Wang X, Lu Y, Gao YJ. Increased CXCL13 and CXCR5 in anterior cingulate cortex contributes to neuropathic pain-related conditioned place aversion. Neurosci Bull 2019, 35: 613–623.

    Article  Google Scholar 

  3. Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, Dworkin RH, et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol 2015, 14: 162–173.

    CAS  Article  Google Scholar 

  4. Sun L, Liu R, Guo F, Wen MQ, Ma XL, Li KY, et al. Parabrachial nucleus circuit governs neuropathic pain-like behavior. Nat Commun 2020, 11: 5974.

    CAS  Article  Google Scholar 

  5. Chiang MC, Bowen A, Schier LA, Tupone D, Uddin O, Heinricher MM. Parabrachial complex: a hub for pain and aversion. J Neurosci 2019, 39: 8225–8230.

    CAS  Article  Google Scholar 

  6. Choi S, Hachisuka J, Brett MA, Magee AR, Omori Y, Iqbal NU, et al. Parallel ascending spinal pathways for affective touch and pain. Nature 2020, 587: 258–263.

    CAS  Article  Google Scholar 

  7. Deng J, Zhou H, Lin JK, Shen ZX, Chen WZ, Wang LH, et al. The parabrachial nucleus directly channels spinal nociceptive signals to the intralaminar thalamic nuclei, but not the amygdala. Neuron 2020, 107(909–923): e906.

    Google Scholar 

  8. Rodriguez E, Sakurai K, Xu J, Chen Y, Toda K, Zhao S, et al. A craniofacial-specific monosynaptic circuit enables heightened affective pain. Nat Neurosci 2017, 20: 1734–1743.

    CAS  Article  Google Scholar 

  9. Chiang MC, Nguyen EK, Canto-Bustos M, Papale AE, Oswald AM, Ross SE. Divergent neural pathways emanating from the lateral parabrachial nucleus mediate distinct components of the pain response. Neuron 2020.

  10. Palmiter RD. The parabrachial nucleus: CGRP neurons function as a general alarm. Trends Neurosci 2018, 41: 280–293.

    CAS  Article  Google Scholar 

  11. Barik A, Thompson JH, Seltzer M, Ghitani N, Chesler AT. A brainstem-spinal circuit controlling nocifensive behavior. Neuron 2018, 100(1491–1503): e1493.

    Google Scholar 

  12. Roeder Z, Chen Q, Davis S, Carlson JD, Tupone D, Heinricher MM. Parabrachial complex links pain transmission to descending pain modulation. Pain 2016, 157: 2697–2708.

    Article  Google Scholar 

  13. Raver C, Uddin O, Ji Y, Li Y, Cramer N, Jenne C, et al. An amygdalo-parabrachial pathway regulates pain perception and chronic pain. J Neurosci 2020, 40: 3424–3442.

    CAS  Article  Google Scholar 

Download references


This Research Highlight was supported by Duke University Anesthesiology Research Funds and the National Natural Science Foundation of China (31771162).

Author information

Authors and Affiliations


Corresponding authors

Correspondence to Zilong Wang or Zhen-Zhong Xu.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Wang, Z., Xu, ZZ. The Parabrachial Nucleus as a Key Regulator of Neuropathic Pain. Neurosci. Bull. 37, 1079–1081 (2021).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: