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Neuromodulation-Based Stem Cell Therapy in Brain Repair: Recent Advances and Future Perspectives

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Abstract

Stem cell transplantation holds a promising future for central nervous system repair. Current challenges, however, include spatially and temporally defined cell differentiation and maturation, plus the integration of transplanted neural cells into host circuits. Here we discuss the potential advantages of neuromodulation-based stem cell therapy, which can improve the viability and proliferation of stem cells, guide migration to the repair site, orchestrate the differentiation process, and promote the integration of neural circuitry for functional rehabilitation. All these advantages of neuromodulation make it one potentially valuable tool for further improving the efficiency of stem cell transplantation.

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Acknowledgements

This review was supported by the National Key R&D Program of China (No. 2020YFA0113600 and 2017YFA0105201), National Natural Sciences Foundation of China (81822017 and 32070955). We thank our lab members for help during manuscript preparation.

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Author notes

  1. Ti-Fei Yuan, Yi Dong and Li Zhang have contributed equally to this review.

Authors and Affiliations

  1. Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China

    Ti-Fei Yuan

  2. State Key Laboratory of Brain and Cognitive Sciences, the University of Hong Kong, Jiulong, Hong Kong SAR, China

    Ti-Fei Yuan & Kwok-Fai So

  3. Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China

    Ti-Fei Yuan, Chun Yao, Yongjun Wang, Renjie Chai & Yan Liu

  4. Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, Shanghai, 200241, China

    Yi Dong

  5. Joint International Research Laboratory of CNS Regeneration, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China

    Li Zhang & Kwok-Fai So

  6. Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, Guangzhou, 510632, China

    Li Zhang & Kwok-Fai So

  7. Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing, 210096, China

    Jieyu Qi & Renjie Chai

  8. Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China

    Chun Yao & Yongjun Wang

  9. Institute for Stem Cell and Neural Regeneration, State Key Laboratory of Reproductive Medicine, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China

    Yan Liu

Authors
  1. Ti-Fei Yuan
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  2. Yi Dong
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  3. Li Zhang
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  4. Jieyu Qi
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  6. Yongjun Wang
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  7. Renjie Chai
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  8. Yan Liu
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  9. Kwok-Fai So
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Corresponding authors

Correspondence to Yongjun Wang, Renjie Chai, Yan Liu or Kwok-Fai So.

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Yuan, TF., Dong, Y., Zhang, L. et al. Neuromodulation-Based Stem Cell Therapy in Brain Repair: Recent Advances and Future Perspectives. Neurosci. Bull. 37, 735–745 (2021). https://doi.org/10.1007/s12264-021-00667-y

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  • DOI: https://doi.org/10.1007/s12264-021-00667-y

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