References
Sharif B, Ase AR, Ribeiro-da-Silva A, Séguéla P. Differential coding of itch and pain by a subpopulation of primary afferent neurons. Neuron 2020, 106: 940–951.
Sun S, Xu Q, Guo C, Guan Y, Liu Q, Dong X. Leaky gate model: intensity-dependent coding of pain and itch in the spinal cord. Neuron 2017, 93: 840–853.
Liu T, Ji RR. Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice. Neurosci Bull 2012, 28: 145–154.
Cheng RX, Feng Y, Liu D, Wang ZH, Zhang JT, Chen LH, et al The role of Nav1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes. Theranostics 2019, 9: 4287–4307.
Han Q, Liu D, Convertino M, Wang Z, Jiang C, Kim YH. miRNA-711 binds and activates TRPA1 extracellularly to evoke acute and chronic pruritus. Neuron 2018, 99: 449–463.
Esancy K, Condon L, Feng J, Kimball C, Curtright A, Dhaka A. A zebrafish and mouse model for selective pruritus via direct activation of TRPA1. Elife 2018, 7: e32036.
McNamara CR, Mandel-Brehm J, Bautista DM, Siemens J, Deranian KL, Zhao M, et al. TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci U S A 2007, 104: 13525–13530.
Zhang H, Cang CL, Kawasaki Y, Liang LL, Zhang YQ, Ji RR, et al. Neurokinin-1 receptor enhances trpv1 activity in primary sensory neurons via pkcepsilon: a novel pathway for heat hyperalgesia. J Neurosci 2007, 27: 12067–12077.
Azimi E, Reddy VB, Pereira PJS, Talbot S, Woolf CJ, Lerner EA. Substance P activates mas-related G protein-coupled receptors to induce itch. J Allergy Clin Immunol 2017, 140: 447–453.
Petitjean H, Séguéla P, Sharif-Naeini R. Bursting enables GRP neurons to engage spinal itch circuits. Neuron 2019, 103: 5–7.
Acknowledgements
This Research Highlight was supported by grants from the National Natural Science Foundation of China (81870874), the Natural Science Foundation of Jiangsu Province, China (BK20170004), and Jiangsu Key Laboratory of Neuropsychiatric Diseases (BM2013003).
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Hu, Y., Shan, WQ., Wu, B. et al. New Insight into the Origins of Itch and Pain: How are Itch and Pain Signals Coded and Discriminated by Primary Sensory Neurons?. Neurosci. Bull. 37, 575–578 (2021). https://doi.org/10.1007/s12264-021-00643-6
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DOI: https://doi.org/10.1007/s12264-021-00643-6