References
Lei P, Ayton S, Finkelstein DI, Spoerri L, Ciccotosto GD, Wright DK. Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export. Nat Med 2012, 18: 291–295.
Park L, Hochrainer K, Hattori Y, Ahn SJ, Anfray A, Wang G, et al. Tau induces PSD95-neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration. Nat Neurosci 2020, 23: 1079–1089.
Brenman JE, Chao DS, Gee SH, McGee AW, Craven SE, Santillano DR, et al. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains. Cell 1996, 84: 757–767.
Aarts M, Liu Y, Liu L, Besshoh S, Arundine M, Gurd JW, et al. Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions. Science 2002, 298: 846–850.
Ramsden M, Kotilinek L, Forster C, Paulson J, McGowan E, Santa Cruz K, et al. Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L). J Neurosci 2005, 25: 10637–10647.
Yoshiyama Y, Higuchi M, Zhang B, Huang SM, Iwata N, Saido TC, et al. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 2007, 53: 337–351.
Lei P, Ayton S, Moon S, Zhang Q, Volitakis I, Finkelstein DI, et al. Motor and cognitive deficits in aged tau knockout mice in two background strains. Mol Neurodegener 2014, 9: 29.
Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J, et al. Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer’s disease mouse models. Cell 2010, 142: 387–397.
Tuo QZ, Lei P, Jackman KA, Li XL, Xiong H, Li XL, et al. Tau-mediated iron export prevents ferroptotic damage after ischemic stroke. Mol Psychiatry 2017, 22: 1520–1530.
Bi M, Gladbach A, van Eersel J, Ittner A, Przybyla M, van Hummel A, et al. Tau exacerbates excitotoxic brain damage in an animal model of stroke. Nat Commun 2017, 8: 473.
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This research highlight was supported by the National Natural Science Foundation of China (81722016).
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Tang, F., Wang, Q., Guo, J. et al. Tau Modulates Neurovascular Coupling. Neurosci. Bull. 37, 433–435 (2021). https://doi.org/10.1007/s12264-021-00637-4
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DOI: https://doi.org/10.1007/s12264-021-00637-4