Mesophasic Assembly of Inhibitory Postsynaptic Density

Neuroscience Bulletin (2020)Cite this article

This is a preview of subscription content, log in to check access.

Access options

Buy single article

Instant access to the full article PDF.

US$ 39.95

Tax calculation will be finalised during checkout.

Fig. 1

References

  1. 1.

    Carlin RK, Grab DJ, Cohen RS, Siekevitz P. Isolation and characterization of postsynaptic densities from various brain regions: enrichment of different types of postsynaptic densities. J Cell Biol 1980, 86: 831–845.

    CAS  Article  Google Scholar 

  2. 2.

    Peters A, Palay SL. The morphology of synapses. J Neurocytol 1996, 25: 687–700.

    CAS  Article  Google Scholar 

  3. 3.

    Colonnier M. Synaptic patterns on different cell types in the different laminae of the cat visual cortex. An electron microscope study. Brain Res 1968, 9: 268–287.

    CAS  PubMed  Google Scholar 

  4. 4.

    Tao CL, Liu YT, Sun R, Zhang B, Qi L, Shivakoti S, et al. Differentiation and characterization of excitatory and inhibitory synapses by cryo-electron tomography and correlative microscopy. J Neurosci 2018, 38: 1493–1510.

    CAS  Article  Google Scholar 

  5. 5.

    Liu YT, Tao CL, Zhang X, Xia W, Shi DQ, Qi L, et al. Mesophasic organization of GABAA receptors in hippocampal inhibitory synapses. Nat Neurosci 2020, 23: 1589–1596.

    Article  Google Scholar 

  6. 6.

    Zeng M, Chen X, Guan D, Xu J, Wu H, Tong P, et al. Reconstituted postsynaptic density as a molecular platform for understanding synapse formation and plasticity. Cell 2018, 174: 1172–1187 e1116.

    Google Scholar 

  7. 7.

    Chen X, Wu X, Wu H, Zhang M. Phase separation at the synapse. Nat Neurosci 2020, 23: 301–310.

    CAS  Article  Google Scholar 

  8. 8.

    Pfeiffer F, Graham D, Betz H. Purification by affinity chromatography of the glycine receptor of rat spinal cord. J Biol Chem 1982, 257: 9389–9393.

    CAS  PubMed  Google Scholar 

  9. 9.

    Kasaragod VB, Schindelin H. Structure-function relationships of glycine and GABAA receptors and their interplay with the scaffolding protein gephyrin. Front Mol Neurosci 2018, 11: 317.

    Article  Google Scholar 

  10. 10.

    Bai G, Wang Y, Zhang M. Gephyrin-mediated formation of inhibitory postsynaptic density sheet via phase separation. Cell Res 2020. https://doi.org/10.1038/s41422-020-00433-1.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgments

Work in our laboratory was supported by grants from the Ministry of Science and Technology of China (2019YFA0508402) and the Research Grant Council of Hong Kong (AoE-M09-12 and C6004-17G). MZ is a Kerry Holdings Professor of Science and a Senior Fellow of the Institute for Advanced Study at HKUST. We thank Drs Changlu Tao and Guoqiang Bi for providing the images used in Figure 1A, B.

Author information

Affiliations

  1. Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China

    Guanhua Bai & Mingjie Zhang

  2. School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, China

    Mingjie Zhang

Authors
  1. Guanhua Bai
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mingjie Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mingjie Zhang.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Bai, G., Zhang, M. Mesophasic Assembly of Inhibitory Postsynaptic Density. Neurosci. Bull. (2020). https://doi.org/10.1007/s12264-020-00623-2

Download citation