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Carlin RK, Grab DJ, Cohen RS, Siekevitz P. Isolation and characterization of postsynaptic densities from various brain regions: enrichment of different types of postsynaptic densities. J Cell Biol 1980, 86: 831–845.
Peters A, Palay SL. The morphology of synapses. J Neurocytol 1996, 25: 687–700.
Colonnier M. Synaptic patterns on different cell types in the different laminae of the cat visual cortex. An electron microscope study. Brain Res 1968, 9: 268–287.
Tao CL, Liu YT, Sun R, Zhang B, Qi L, Shivakoti S, et al. Differentiation and characterization of excitatory and inhibitory synapses by cryo-electron tomography and correlative microscopy. J Neurosci 2018, 38: 1493–1510.
Liu YT, Tao CL, Zhang X, Xia W, Shi DQ, Qi L, et al. Mesophasic organization of GABAA receptors in hippocampal inhibitory synapses. Nat Neurosci 2020, 23: 1589–1596.
Zeng M, Chen X, Guan D, Xu J, Wu H, Tong P, et al. Reconstituted postsynaptic density as a molecular platform for understanding synapse formation and plasticity. Cell 2018, 174: 1172–1187 e1116.
Chen X, Wu X, Wu H, Zhang M. Phase separation at the synapse. Nat Neurosci 2020, 23: 301–310.
Pfeiffer F, Graham D, Betz H. Purification by affinity chromatography of the glycine receptor of rat spinal cord. J Biol Chem 1982, 257: 9389–9393.
Kasaragod VB, Schindelin H. Structure-function relationships of glycine and GABAA receptors and their interplay with the scaffolding protein gephyrin. Front Mol Neurosci 2018, 11: 317.
Bai G, Wang Y, Zhang M. Gephyrin-mediated formation of inhibitory postsynaptic density sheet via phase separation. Cell Res 2020. https://doi.org/10.1038/s41422-020-00433-1.
Work in our laboratory was supported by grants from the Ministry of Science and Technology of China (2019YFA0508402) and the Research Grant Council of Hong Kong (AoE-M09-12 and C6004-17G). MZ is a Kerry Holdings Professor of Science and a Senior Fellow of the Institute for Advanced Study at HKUST. We thank Drs Changlu Tao and Guoqiang Bi for providing the images used in Figure 1A, B.
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Bai, G., Zhang, M. Mesophasic Assembly of Inhibitory Postsynaptic Density. Neurosci. Bull. (2020). https://doi.org/10.1007/s12264-020-00623-2