Lin28a is Essential for Synaptic Plasticity in Dentate Granule Cells and Spatial Memory

This is a preview of subscription content, log in to check access.

Fig. 1
Fig. 2

References

  1. 1.

    Gu Y, Janoschka S, Ge S. Neurogenesis and hippocampal plasticity in adult brain. Curr Top Behav Neurosci 2013, 15: 31–48.

    CAS  Article  Google Scholar 

  2. 2.

    Hainmueller T,Bartos M. Dentate gyrus circuits for encoding, retrieval and discrimination of episodic memories. Nat Rev Neurosci 2020, 21: 153–168.

    CAS  Article  Google Scholar 

  3. 3.

    Shyh-Chang N,Daley GQ. Lin28: primal regulator of growth and metabolism in stem cells. Cell Stem Cell 2013, 12: 395–406.

    Article  Google Scholar 

  4. 4.

    Yang M, Yang SL, Herrlinger S, Liang C, Dzieciatkowska M, Hansen KC, et al. Lin28 promotes the proliferative capacity of neural progenitor cells in brain development. Development 2015, 142: 1616–1627.

    CAS  Article  Google Scholar 

  5. 5.

    Cimadamore F, Amador-Arjona A, Chen C, Huang CT, Terskikh AV. SOX2-LIN28/let-7 pathway regulates proliferation and neurogenesis in neural precursors. Proc Natl Acad Sci U S A 2013, 110: E3017–E3026.

    CAS  Article  Google Scholar 

  6. 6.

    Yao K, Qiu S, Tian L, Snider WD, Flannery JG, Schaffer DV, et al. Wnt regulates proliferation and neurogenic potential of muller glial cells via a Lin28/let-7 miRNA-dependent pathway in adult mammalian retinas. Cell Rep 2016, 17: 165–178.

    CAS  Article  Google Scholar 

  7. 7.

    Hainmueller T,Bartos M. Parallel emergence of stable and dynamic memory engrams in the hippocampus. Nature 2018, 558: 292–296.

    CAS  Article  Google Scholar 

  8. 8.

    Kheirbek MA, Drew LJ, Burghardt NS, Costantini DO, Tannenholz L, Ahmari SE, et al. Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus. Neuron 2013, 77: 955–968.

    CAS  Article  Google Scholar 

  9. 9.

    Harris JJ, Jolivet R, Attwell D. Synaptic energy use and supply. Neuron 2012, 75(5): 762–777.

    CAS  Article  Google Scholar 

  10. 10.

    Tang SJ, Reis G, Kang H, Gingras AC, Sonenberg N, Schuman EM. A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus. Proc Natl Acad Sci U S A 2002, 99: 467–472.

    CAS  Article  Google Scholar 

  11. 11.

    Jun-Hao ET, Gupta RR, Shyh-Chang N. Lin28 and let-7 in the metabolic physiology of aging. Trends Endocrinol Metab 2016, 27: 132–141.

    CAS  Article  Google Scholar 

  12. 12.

    Hall CN, Klein-Flugge MC, Howarth C, Attwell D. Oxidative phosphorylation, not glycolysis, powers presynaptic and postsynaptic mechanisms underlying brain information processing. J Neurosci 2012, 32: 8940–8951.

    CAS  Article  Google Scholar 

  13. 13.

    Cunha RA, Vizi ES, Ribeiro JA, Sebastiao AM. Preferential release of ATP and its extracellular catabolism as a source of adenosine upon high- but not low-frequency stimulation of rat hippocampal slices. J Neurochem 1996, 67: 2180–2187.

    CAS  Article  Google Scholar 

  14. 14.

    Gu Y, Arruda-Carvalho M, Wang J, Janoschka SR, Josselyn SA, Frankland PW, et al. Optical controlling reveals time-dependent roles for adult-born dentate granule cells. Nat Neurosci 2012, 15: 1700–1706.

    CAS  Article  Google Scholar 

  15. 15.

    Luo H, Liu Z, Liu B, Li H, Yang Y, Xu ZD. Virus-mediated overexpression of ETS-1 in the ventral hippocampus counteracts depression-like behaviors in rats. Neurosci Bull 2019, 35: 1035–1044.

    Article  Google Scholar 

Download references

Acknowledgments

We are grateful to the Core Facilities of Zhejiang University School of Medicine for technical assistance. This work was supported by grants from the National Key R&D Program of China (2017YFA0104200), the Natural Science Foundation of Zhejiang Province, China (LR17C090001), and startup funds to YG.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Yan Gu.

Ethics declarations

Conflict of interests

All authors declare no conflict of interests.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (PDF 107 kb)

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Hu, Z., Ma, J. & Gu, Y. Lin28a is Essential for Synaptic Plasticity in Dentate Granule Cells and Spatial Memory. Neurosci. Bull. (2020). https://doi.org/10.1007/s12264-020-00591-7

Download citation