Axonal Iron Transport might Contribute to Iron Deposition in Parkinson’s Disease

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References

  1. 1.

    Thomas GEC, Leyland LA, Schrag AE, Lees AJ, Acosta-Cabronero J, Weil RS. Brain iron deposition is linked with cognitive severity in Parkinson’s disease. J Neurol Neurosurg Psychiatry 2020, 91: 418–425.

    Article  Google Scholar 

  2. 2.

    Jonkman LE, Kenkhuis B, Geurts JJG, van de Berg WDJ. Post-mortem MRI and histopathology in neurologic disease: a translational approach. Neurosci Bull 2019, 35: 229–243.

    Article  Google Scholar 

  3. 3.

    Moreau C, Duce JA, Rascol O, Devedjian JC, Berg D, Dexter D, et al. Iron as a therapeutic target for Parkinson’s disease. Movement Disorders 2018, 33: 568–574.

    Article  Google Scholar 

  4. 4.

    Bingbing Chen XW, Hong Jiang, Jun Wang, Ning Song, Junxia Xie. Interactions between iron and α-synuclein pathology in Parkinson’s disease. Free Radical Biology and Medicine 2019, 141: 253–260.

  5. 5.

    Song N, Wang J, Jiang H, Xie J. Astroglial and microglial contributions to iron metabolism disturbance in Parkinson’s disease. Biochim Biophys Acta Mol Basis Dis 2018, 1864: 967–973.

    CAS  Article  Google Scholar 

  6. 6.

    Wang Z, Zeng YN, Yang P, Jin LQ, Xiong WC, Zhu MZ, et al. Axonal iron transport in the brain modulates anxiety-related behaviors. Nat Chem Biol 2019, 15: 1214–1222.

    CAS  Article  Google Scholar 

  7. 7.

    Yu X, Du T, Song N, He Q, Shen Y, Jiang H, et al. Decreased iron levels in the temporal cortex in postmortem human brains with Parkinson disease. Neurology 2013, 80: 492–495.

    CAS  Article  Google Scholar 

  8. 8.

    Salazar J, Mena N, Hunot S, Prigent A, Alvarez-Fischer D, Arredondo M, et al. Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson’s disease. Proc Natl Acad Sci USA 2008, 105: 18578–18583.

    CAS  Article  Google Scholar 

  9. 9.

    Jia Y, Deng H, Qin Q, Ma Z. JWH133 inhibits MPP(+)-induced inflammatory response and iron influx in astrocytes. Neurosci Lett 2020, 720: 134779–134785.

    CAS  Article  Google Scholar 

  10. 10.

    Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, et al. Reversing a model of Parkinson’s disease with in situ converted nigral neurons. Nature 2020, 582: 550–556.

    CAS  Article  Google Scholar 

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Acknowledgements

This highlight article was supported by grants from the National Natural Science Foundation of China (31800893 and 31771124), and Shandong Provincial Natural Science Foundation (ZR2019BC008).

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Correspondence to Junxia Xie.

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Chen, L., Li, C. & Xie, J. Axonal Iron Transport might Contribute to Iron Deposition in Parkinson’s Disease. Neurosci. Bull. (2020). https://doi.org/10.1007/s12264-020-00585-5

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