This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Thomas GEC, Leyland LA, Schrag AE, Lees AJ, Acosta-Cabronero J, Weil RS. Brain iron deposition is linked with cognitive severity in Parkinson’s disease. J Neurol Neurosurg Psychiatry 2020, 91: 418–425.
Jonkman LE, Kenkhuis B, Geurts JJG, van de Berg WDJ. Post-mortem MRI and histopathology in neurologic disease: a translational approach. Neurosci Bull 2019, 35: 229–243.
Moreau C, Duce JA, Rascol O, Devedjian JC, Berg D, Dexter D, et al. Iron as a therapeutic target for Parkinson’s disease. Movement Disorders 2018, 33: 568–574.
Bingbing Chen XW, Hong Jiang, Jun Wang, Ning Song, Junxia Xie. Interactions between iron and α-synuclein pathology in Parkinson’s disease. Free Radical Biology and Medicine 2019, 141: 253–260.
Song N, Wang J, Jiang H, Xie J. Astroglial and microglial contributions to iron metabolism disturbance in Parkinson’s disease. Biochim Biophys Acta Mol Basis Dis 2018, 1864: 967–973.
Wang Z, Zeng YN, Yang P, Jin LQ, Xiong WC, Zhu MZ, et al. Axonal iron transport in the brain modulates anxiety-related behaviors. Nat Chem Biol 2019, 15: 1214–1222.
Yu X, Du T, Song N, He Q, Shen Y, Jiang H, et al. Decreased iron levels in the temporal cortex in postmortem human brains with Parkinson disease. Neurology 2013, 80: 492–495.
Salazar J, Mena N, Hunot S, Prigent A, Alvarez-Fischer D, Arredondo M, et al. Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson’s disease. Proc Natl Acad Sci USA 2008, 105: 18578–18583.
Jia Y, Deng H, Qin Q, Ma Z. JWH133 inhibits MPP(+)-induced inflammatory response and iron influx in astrocytes. Neurosci Lett 2020, 720: 134779–134785.
Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, et al. Reversing a model of Parkinson’s disease with in situ converted nigral neurons. Nature 2020, 582: 550–556.
This highlight article was supported by grants from the National Natural Science Foundation of China (31800893 and 31771124), and Shandong Provincial Natural Science Foundation (ZR2019BC008).
About this article
Cite this article
Chen, L., Li, C. & Xie, J. Axonal Iron Transport might Contribute to Iron Deposition in Parkinson’s Disease. Neurosci. Bull. (2020). https://doi.org/10.1007/s12264-020-00585-5