This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Bondeson DP, Mares A, Smith IE, Ko E, Campos S, Miah AH, et al. Catalytic in vivo protein knockdown by small-molecule PROTACs. Nat Chem Biol 2015, 11: 611–617.
Li Z, Wang C, Wang Z, Zhu C, Li J, Sha T, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature 2019, 575: 203–209.
Winter GE, Buckley DL, Paulk J, Roberts JM, Souza A, Dhe-Paganon S, et al. Drug Development. Phthalimide conjugation as a strategy for in vivo target protein degradation. Science 2015, 348: 1376–1381.
Dubois JM, Ouanounou G, Rouzaire-Dubois B. The Boltzmann equation in molecular biology. Prog Biophys Mol Biol 2009, 99: 87–93.
Douglass EF, Jr., Miller CJ, Sparer G, Shapiro H, Spiegel DA. A comprehensive mathematical model for three-body binding equilibria. J Am Chem Soc 2013, 135: 6092–6099.
Schapira M, Calabrese MF, Bullock AN, Crews CM. Targeted protein degradation: expanding the toolbox. Nat Rev Drug Discov 2019, 18: 949–963.
Zhang Y, Loh C, Chen J, Mainolfi N. Targeted protein degradation mechanisms. Drug Discov Today Technol 2019, 31: 53–60.
Crisp MJ, Mawuenyega KG, Patterson BW, Reddy NC, Chott R, Self WK, et al. In vivo kinetic approach reveals slow SOD1 turnover in the CNS. J Clin Invest 2015, 125: 2772–2780.
Li Q, Wang L, Ma Y, Yue W, Zhang D, Li J. P-Rex1 overexpression results in aberrant neuronal polarity and psychosis-related behaviors. Neurosci Bull 2019, 35: 1011–1023.
Chang Q, Yang H, Wang M, Wei H, Hu F. Role of microtubule-associated protein in autism spectrum disorder. Neurosci Bull 2018, 34: 1119–1126.
This work was supported by the National Natural Science Foundation of China (81925012, 81870990, and 31961130379) and a Newton Advanced Fellowship (NAF_R1_191045).
Conflict of interest
The authors declare that they have no conflict of interest.
Electronic supplementary material
Below is the link to the electronic supplementary material.
About this article
Cite this article
Zhang, H., An, P., Fei, Y. et al. Modeling the Degradation Effects of Autophagosome Tethering Compounds. Neurosci. Bull. (2020). https://doi.org/10.1007/s12264-020-00574-8