This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Tax calculation will be finalised during checkout.
Eltzschig HK, Eckle T. Ischemia and reperfusion-from mechanism to translation. Nat Med 2011, 17: 1391–1401.
Mo JL, Pan ZG, Chen X, Lei Y, Lv LL, Qian C, et al. MicroRNA-365 knockdown prevents ischemic neuronal injury by activating oxidation resistance 1-mediated antioxidant signals. Neurosci Bull 2019, 35: 815–825.
Karsy M, Brock A, Guan J, Taussky P, Yashar M, Park MS. Neuroprotective strategies and the underlying molecular basis of cerebrovascular stroke. Neurosurg Focus 2017, 42: E3. https://doi.org/10.3171/2017.1.focus16522.
Campbell JB, Overby PF, Gray AE, Smith HC, Harrison JF. Genome-wide association analysis of anoxia tolerance in Drosophila melanogaster. G3 Genes Genomes Genet 2019, 9: 2989–2999.
Zhou D, Visk DW, Haddad GG. Drosophila, a golden bug, for the dissection of the genetic basis of tolerance and susceptibility to hypoxia. Pediatr Res 2009, 66: 239–247.
Pandey UB, Nichols CD. Human disease models in drosophila melanogaster and the role of the fly in therapeutic drug discovery. Pharmacol Rev 2011, 63: 411–436.
Zhao XL, Wang WA, Tan JX, Huang JK, Zhang X, Zhang BZ, et al. Expression of -amyloid induced age-dependent presynaptic and axonal changes in Drosophila. J Neurosci 2010, 30: 1512–1522.
Liu H, Han M, Li Q, Zhang X, Wang WA, Huang FD. Automated rapid iterative negative geotaxis assay and its use in a genetic screen for modifiers of Aβ42-induced locomotor decline in Drosophila. Neurosci Bull 2015, 31: 541–549.
He Y, Wei M, Wu Y, Qin H, Li W, Ma X, et al. Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate. Nat Commun 2019, 10: 1193.
Xia Y, Xu W, Meng S, Lim NKH, Wang W, Huang FD. An efficient and reliable assay for investigating the effects of hypoxia/anoxia on Drosophila. Neurosci Bull 2018, 34: 397–402.
Zhang L, Ali Syed Z, Van Dijk H’rd I, Lim JM, Wells L, Ten Hagen KG. O-Glycosylation regulates polarized secretion by modulating Tango1 stability. Proc Natl Acad Sci U S A. 2014, 111: 7296–7301.
Saito K, Chen M, Bard F, Chen S, Zhou H, Woodley D, et al. TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites. Cell 2009, 136: 891–902.
Ten Hagen KG, Tran DT, Gerken TA, Stein DS, Zhang Z. Functional characterization and expression analysis of members of the UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase family from Drosophila melanogaster. J Biol Chem 2003, 278: 35039–35048.
Ishikawa Y, Ito S, Nagata K, Sakai LY, Bächinger HP. Intracellular mechanisms of molecular recognition and sorting for transport of large extracellular matrix molecules. Proc Natl Acad Sci U S A 2016, 113: E6036–E6044.
Sicari D, Igbaria A, Chevet E. Control of protein homeostasis in the early secretory pathway: current status and challenges. Cells 2019, 8: 1347. https://doi.org/10.3390/cells8111347.
This work was supported by the National Natural Science Foundation of China (81771416, 81650110527 and 8197100), Shanghai Municipal Commission of Health and Family Planning (201740153) and Key Discipline of Chongming District, Shanghai, China, 2018.
Conflict of interest
Fude Huang’s research in this study received financial support from Nuo-Beta Pharmaceutical Technology (Shanghai) Co., Ltd (Nuo-Beta), Fude Huang and Wenan Wang have share holdings in Nuo-Beta. The other authors declare no competing financial interests.
Electronic supplementary material
Below is the link to the electronic supplementary material.
About this article
Cite this article
Du, Q., Lim, N.K.H., Xia, Y. et al. Pgant4 and Tango1 Mediate Anoxia and Reoxygenation Injury. Neurosci. Bull. 36, 1552–1557 (2020). https://doi.org/10.1007/s12264-020-00562-y