Cortical Astrocyte-neuronal Metabolic Coupling Emerges as a Critical Modulator of Stress-induced Hopelessness

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  1. 1.

    Krishnan V, Nestler EJ. The molecular neurobiology of depression. Nature 2008, 455: 894–902.

    CAS  Article  Google Scholar 

  2. 2.

    Bagot RC, Parise EM, Pena CJ, Zhang HX, Maze I, Chaudhury D, et al. Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression. Nat Commun 2015, 6: 7062.

    CAS  Article  Google Scholar 

  3. 3.

    Cook SC, Wellman CL. Chronic stress alters dendritic morphology in rat medial prefrontal cortex. J Neurobiol 2004, 60: 236–248.

    Article  Google Scholar 

  4. 4.

    Yin YN, Hu J, Wei YL, Li ZL, Luo ZC, Wang RQ, et al. Astrocyte-derived lactate modulates the passive coping response to behavioral challenge in male mice. Neurosci Bull 2020.

    Article  PubMed  PubMed Central  Google Scholar 

  5. 5.

    Barros LF, Weber B. CrossTalk proposal: an important astrocyte-to-neuron lactate shuttle couples neuronal activity to glucose utilisation in the brain. J Physiol 2018, 596: 347–350.

    CAS  Article  Google Scholar 

  6. 6.

    Daniels S, Horman T, Lapointe T, Melanson B, Storace A, Kennedy SH, et al. Reverse translation of major depressive disorder symptoms: A framework for the behavioural phenotyping of putative biomarkers. J Affect Disord 2020, 263: 353–366.

    Article  Google Scholar 

  7. 7.

    Suzuki A, Stern Sarah A, Bozdagi O, Huntley George W, Walker Ruth H, Magistretti Pierre J, et al. Astrocyte-neuron lactate transport is required for long-term memory formation. Cell 2011, 144: 810–823.

    CAS  Article  Google Scholar 

  8. 8.

    Pellerin L, Magistretti PJ. Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci U S A 1994, 91: 10625–10629.

    CAS  Article  Google Scholar 

  9. 9.

    Pierre K, Pellerin L. Monocarboxylate transporters in the central nervous system: distribution, regulation and function. J Neurochem 2005, 94: 1–14.

    CAS  Article  Google Scholar 

  10. 10.

    Gray LR, Tompkins SC, Taylor EB. Regulation of pyruvate metabolism and human disease. Cell Mol Life Sci 2014, 71: 2577–2604.

    CAS  Article  Google Scholar 

  11. 11.

    Diaz-Garcia CM, Mongeon R, Lahmann C, Koveal D, Zucker H, Yellen G. Neuronal stimulation triggers neuronal glycolysis and not lactate uptake. Cell Metab 2017, 26: 361–374 e364.

    Google Scholar 

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Correspondence to Giannina Descalzi.

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Descalzi, G. Cortical Astrocyte-neuronal Metabolic Coupling Emerges as a Critical Modulator of Stress-induced Hopelessness. Neurosci. Bull. (2020).

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