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Purines: From Diagnostic Biomarkers to Therapeutic Agents in Brain Injury

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Abstract

The purines constitute a family of inter-related compounds that serve a broad range of important intracellular and extracellular biological functions. In particular, adenosine triphosphate (ATP) and its metabolite and precursor, adenosine, regulate a wide variety of cellular and systems-level physiological processes extending from ATP acting as the cellular energy currency, to the adenosine arising from the depletion of cellular ATP and responding to reduce energy demand and hence to preserve ATP during times of metabolic stress. This inter-relationship provides opportunities for both the diagnosis of energy depletion during conditions such as stroke, and the replenishment of ATP after such events. In this review we address these opportunities and the broad potential of purines as diagnostics and restorative agents.

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Acknowledgements

We are grateful to the following organizations for funding: Research into Ageing, The Royal Society, The Wellcome Trust, BBSRC, Rosetrees Trust, and The University of Warwick.

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  1. School of Life Sciences, The University Warwick, Coventry, CV4 7AL, UK

    Bruno G. Frenguelli & Nicholas Dale

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Correspondence to Bruno G. Frenguelli.

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Nicholas Dale is the founder, an Executive Director, and the Chief Scientific Officer of Sarissa Biomedical, the company manufacturing the research and diagnostic purine biosensors described in the review. Bruno Frenguelli is a Non-Executive Director of Sarissa Biomedical. Dale and Frenguelli are either employed by Sarissa and/or have shares in the company.

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Frenguelli, B.G., Dale, N. Purines: From Diagnostic Biomarkers to Therapeutic Agents in Brain Injury. Neurosci. Bull. 36, 1315–1326 (2020). https://doi.org/10.1007/s12264-020-00529-z

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