Image-Forming Visual Basis of Empathy for Pain in Mice

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References

  1. 1.

    de Waal FBM, Preston SD. Mammalian empathy: behavioural manifestations and neural basis. Nat Rev Neurosci 2017, 18: 498–509.

    Article  Google Scholar 

  2. 2.

    Chen J. Empathy for distress in humans and rodents. Neurosci Bull 2018, 34: 216–236.

    Article  Google Scholar 

  3. 3.

    Langford DJ, Crager SE, Shehzad Z, Smith SB, Sotocinal SG, Levenstadt JS, et al. Social modulation of pain as evidence for empathy in mice. Science 2006, 312: 1967–1970.

    CAS  Article  Google Scholar 

  4. 4.

    Du R, Luo WJ, Geng KW, Li CL, Yu Y, Wei N, et al. Empathic contagious pain and consolation in laboratory rodents: species and sex comparisons. Neurosci Bull 2020. https://doi.org/10.1007/s12264-020-00465-y.

    Article  PubMed  PubMed Central  Google Scholar 

  5. 5.

    Li CL, Yu Y, He T, Wang RR, Geng KW, Du R, et al. Validating rat model of empathy for pain: effects of pain expressions in social partners. Front Behav Neurosci 2018, 12: 242.

    CAS  Article  Google Scholar 

  6. 6.

    Yu YQ, Barry DM, Hao Y, Liu XT, Chen ZF. Molecular and neural basis of contagious itch behavior in mice. Science 2017, 355: 1072–1076.

    CAS  Article  Google Scholar 

  7. 7.

    Burkett JP, Andari E, Johnson ZV, Curry DC, de Waal FBM, Young LJ. Oxytocin-dependent consolation behavior in rodents. Science 2016, 351: 375–378.

    CAS  Article  Google Scholar 

  8. 8.

    Lamm C, Decety J, Singer T. Meta-analytic evidence for common and distinct neural networks associated with directly experienced pain and empathy for pain. Neuroimage 2011, 54: 2492–2502.

    Article  Google Scholar 

  9. 9.

    Smith ML, Hostetler CM, Heinricher MM, Ryabinin AE. Social transfer of pain in mice. Sci Adv 2016, 2: e1600855.

    Article  Google Scholar 

  10. 10.

    Grimes WN, Songco-Aguas A, Rieke F. Parallel processing of rod and cone signals: retinal function and human perception. Annu Rev Vis Sci 2018, 4: 123–141.

    Article  Google Scholar 

  11. 11.

    Spitschan M, Lucas RJ, Brown TM. Chromatic clocks: color opponency in non-image-forming visual functions. Neurosci Biobehav Rev 2017, 78: 24–33.

    Article  Google Scholar 

  12. 12.

    Allen AE, Storchi R, Martial FP, Bedford RA, Lucas RJ. Melanopsin contributions to the representation of images in the early visual system. Curr Biol 2017, 27: 1623–1632.e4.

    Google Scholar 

  13. 13.

    Sonoda T, Lee SK, Birnbaumer L, Schmidt TM. Melanopsin phototransduction is repurposed by ipRGC subtypes to shape the function of distinct visual circuits. Neuron 2018, 99: 754–767.e4.

    Google Scholar 

  14. 14.

    Glickfeld LL, Olsen SR. Higher-order areas of the mouse visual cortex. Annu Rev Vis Sci 2017, 3: 251–273.

    Article  Google Scholar 

  15. 15.

    Carrillo M, Han YY, Migliorati F, Liu M, Gazzola V, Keysers C. Emotional mirror neurons in the rat’s anterior cingulate cortex. Curr Biol 2019, 29: 1301–1312.e6.

    Google Scholar 

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Acknowledgments

We are grateful to YQ Yu, YJ Yin, Y Yang, and F Yang for cooperation and XL Wang for animal support. This work was supported by grants from the National Natural Science Foundation of China (81571072 and 31600855) and the Military Laboratory Animal Project (SYDW[2017]14 and SYDW[2018]07).

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Correspondence to Zhou-Feng Chen or Jun Chen.

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Geng, KW., Du, R., Wei, N. et al. Image-Forming Visual Basis of Empathy for Pain in Mice. Neurosci. Bull. 36, 1563–1569 (2020). https://doi.org/10.1007/s12264-020-00528-0

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