Microglia Interact with Neurons by Forming Somatic Junctions

A Correction to this article was published on 05 June 2020

This article has been updated

This is a preview of subscription content, access via your institution.

Fig. 1

Change history

  • 05 June 2020

    The original version of this article unfortunately contained two misunderstandings.

References

  1. 1.

    Salter MW, Stevens B. Microglia emerge as central players in brain disease. Nat Med 2017, 23: 1018–1027.

    CAS  Article  Google Scholar 

  2. 2.

    Wake H, Moorhouse AJ, Jinno S, Kohsaka S, Nabekura J. Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J Neurosci 2009, 29: 3974–3980.

    CAS  Article  Google Scholar 

  3. 3.

    Lui H, Zhang J, Makinson SR, Cahill MK, Kelley KW, Huang H-Y, et al. Progranulin deficiency promotes circuit-specific synaptic pruning by microglia via complement activation. Cell 2016, 165: 921–935.

    CAS  Article  Google Scholar 

  4. 4.

    Weinhard L, Di Bartolomei G, Bolasco G, Machado P, Schieber NL, Neniskyte U, et al. Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction. Nat Commun 2018, 9: 1228.

    Article  Google Scholar 

  5. 5.

    Tremblay M-È, Lowery RL, Majewska AK. Microglial interactions with synapses are modulated by visual experience. PLoS Biol 2010, 8: 1–16.

    Article  Google Scholar 

  6. 6.

    Davalos D, Grutzendler J, Yang G, Kim JV, Zuo Y, Jung S, et al. ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 2005, 8: 752–758.

    CAS  Article  Google Scholar 

  7. 7.

    Cserép C, Pósfai B, Lénárt N, Fekete R, László ZI, Lele Z, et al. Microglia monitor and protect neuronal function via specialized somatic purinergic junctions. Science 2019, 367: 528–537.

    Article  Google Scholar 

  8. 8.

    Fletcher EV, Simon CM, Pagiazitis JG, Chalif JI, Vukojicic A, Drobac E, et al. Reduced sensory synaptic excitation impairs motor neuron function via Kv2. 1 in spinal muscular atrophy. Nat Neurosci 2017, 20: 905–916.

    CAS  Article  Google Scholar 

  9. 9.

    Haynes SE, Hollopeter G, Yang G, Kurpius D, Dailey ME, Gan WB, et al. The P2Y 12 receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci 2006, 9: 1512–1519.

    CAS  Article  Google Scholar 

  10. 10.

    Li Y, Du XF, Liu CS, Wen ZL, Du JL. Reciprocal regulation between resting microglial dynamics and neuronal activity in vivo. Dev Cell 2012, 23: 1189–1202.

    CAS  Article  Google Scholar 

  11. 11.

    Ho MS. Neuroglial crosstalk by mitochondria. Neurosci Bull 2017, 33: 111–112.

    Article  Google Scholar 

  12. 12.

    Qin C, Zhou LQ, Ma XT, Hu ZW, Yang S, Chen M, et al. Dual functions of microglia in ischemic stroke. Neurosci Bull 2019, 34: 1–13.

    Google Scholar 

  13. 13.

    Eyo UB, Peng J, Swiatkowski P, Mukherjee A, Bispo A, Wu LJ. Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus. J Neurosci 2014, 34: 10528–10540.

    Article  Google Scholar 

  14. 14.

    Peng J, Liu Y, Umpierre AD, Xie M, Tian DS, Richardson JR, et al. Microglial P2Y12 receptor regulates ventral hippocampal CA1 neuronal excitability and innate fear in mice. Mol Brain 2019, 12: 1–10.

    Article  Google Scholar 

Download references

Acknowledgements

This highlight was supported by the Natural Science Foundation of Zhejiang Province (LR18C090001), the National Natural Science Foundation of China (31671071 and 81801102), the National Postdoctoral Science Foundation of China (2018M642413 and 2019T120507), and the Research Start-up Project by Hangzhou Normal University (4125C5021920453).

Author information

Affiliations

Authors

Corresponding author

Correspondence to Zhihui Huang.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Wang, Y., Huang, Z. Microglia Interact with Neurons by Forming Somatic Junctions. Neurosci. Bull. 36, 1085–1088 (2020). https://doi.org/10.1007/s12264-020-00517-3

Download citation