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A Lower-Brainstem Structure Coordinates Acquisition of Negative Experience

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References

  1. Gross CT, Canteras NS. The many paths to fear. Nat Rev Neurosci 2012, 13: 651–658.

    Article  CAS  Google Scholar 

  2. Wang L, Chen IZ, Lin D. Collateral pathways from the ventromedial hypothalamus mediate defensive behaviors. Neuron 2015, 85: 1344–1358.

    Article  CAS  Google Scholar 

  3. Szőnyi A, Zichó K, Barth AM, Gönczi RT, Schlingloff D, Török B, et al. Median raphe controls acquisition of negative experience in the mouse. Science 2019, 366: eaay8746.

    Article  Google Scholar 

  4. Cao X, Li LP, Wang Q, Wu Q, Hu HH, Zhang M, et al. Astrocyte-derived ATP modulates depressive-like behaviors. Nat Med 2013, 19: 773–777.

    Article  CAS  Google Scholar 

  5. Cui Y, Yang Y, Ni Z, Dong Y, Cai G, Foncelle A, et al. Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression. Nature 2018, 554: 323–327.

    Article  CAS  Google Scholar 

  6. Li L, Feng X, Zhou Z, Zhang H, Shi Q, Lei Z, et al. Stress accelerates defensive responses to looming in mice and involves a locus coeruleus-superior colliculus projection. Curr Biol 2018, 28: 859–871 e855.

    Google Scholar 

  7. Li Y, Zeng J, Zhang J, Yue C, Zhong W, Liu Z, et al. Hypothalamic circuits for predation and evasion. Neuron 2018, 97: 911–924 e915.

    Google Scholar 

  8. Yang H, Yang J, Xi W, Hao S, Luo B, He X, et al. Laterodorsal tegmentum interneuron subtypes oppositely regulate olfactory cue-induced innate fear. Nat Neurosci 2016, 19: 283–289.

    Article  CAS  Google Scholar 

  9. Luo H, Liu Z, Liu B, Li H, Yang Y, Xu ZD. Virus-mediated overexpression of ETS-1 in the ventral hippocampus counteracts depression-like behaviors in rats. Neurosci Bull 2019, 35: 1035–1044.

    Article  Google Scholar 

  10. Tang N, Ding YF, Zhang W, Hu J, Xu XH. Stay active to cope with fear: a cortico-intrathalamic pathway for conditioned flight behavior. Neurosci Bull 2019, 35: 1116–1119.

    Article  CAS  Google Scholar 

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Acknowledgements:

This research highlight article was supported by the National Natural Science Foundation of China (31971072 and 81671444), Guangdong International Cooperation Grant (2019A050510032), Shenzhen Science and Technology Innovation Committee Fund (JCYJ20180508152336419), and Guangdong Provincial Key Laboratory of Brain Connectome and Behavior (2017B030301017).

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  1. Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518000, China

    Lei Li

  2. Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, 518055, China

    Lei Li

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  1. Lei Li
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Correspondence to Lei Li.

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Li, L. A Lower-Brainstem Structure Coordinates Acquisition of Negative Experience. Neurosci. Bull. 36, 955–957 (2020). https://doi.org/10.1007/s12264-020-00504-8

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  • DOI: https://doi.org/10.1007/s12264-020-00504-8

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